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Steroid compound, preparation method thereof, medicinal composition containing compound and application of compounds

A technology of steroidal compounds and medicinal residues, applied in the field of medicinal chemistry, can solve problems such as unclear ingredients, unstable curative effect, and unclear mechanism of action

Inactive Publication Date: 2011-06-29
CHONGQING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its superiority is manifested in that it can significantly improve the symptoms and quality of life of patients, and play a regulatory role through multi-target effects, but the ingredients are not clear, the mechanism of action is not clear, and the curative effect is unstable

Method used

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  • Steroid compound, preparation method thereof, medicinal composition containing compound and application of compounds
  • Steroid compound, preparation method thereof, medicinal composition containing compound and application of compounds
  • Steroid compound, preparation method thereof, medicinal composition containing compound and application of compounds

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preparation example

[0049] The compound of the present invention is isolated from the traditional Chinese herbal medicine Radix Ophiopogon japonicus. After the determination of physical and chemical properties, ultraviolet, infrared, mass spectrum and nuclear magnetic resonance spectrum analysis, it is finally confirmed that the compound is a steroid compound, and its chemical name is 14,16-dihydroxy dioscorea Saponin, also known as diol diosgenin (14,16-Dihydrodiogenin), has the following chemical structure:

[0050]

[0051] Wherein, for how to isolate the compound from Cininggong Ophiopogon japonicus, specifically include the following steps:

[0052] Step 1: Take 1000kg of Ophiopogon japonicus, put it in an extraction kettle, add water to boil at 7 times the weight, keep at 80-90°C for 2 hours, filter, add water to boil at 80-90°C at 4 times the weight, and keep at 80-90°C for 1.5 hours , filtered, and the dregs were 4 times the weight, boiled with water, kept at 80-90°C for 1 hour, and fi...

preparation example 1

[0061] Diol diosgenin preparation example 1: Preparation of tablet

[0062] With formula I as raw material, prepare diol diosgenin tablet, the formula of 1000 tablets is as follows:

[0063] Diol diosgenin tablets (in C 27 h 46 o 5 count)

[0064] 30

[0065] Mix the raw materials and auxiliary materials, grind them into fine powder, pass through a 100-mesh sieve, take the amount according to the formula, press into tablets, and pack.

preparation example 2

[0066] Diol diosgenin preparation example 2: Preparation of diol diosgenin capsules

[0067]With formula I as raw material, prepare diol diosgenin capsules, the formula of 1000 capsules is as follows:

[0068] Diol diosgenin capsules (in C 27 h 46 o 5 count)

[0069] Mix the raw materials and auxiliary materials, grind them into fine powder, pass through a 100-mesh sieve, take the amount according to the formula, granulate and pack.

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Abstract

The invention provides a steroid compound, a preparation method thereof, a medicinal composition containing the compound and application of the compounds, which belong to the technical field of medicaments. The steroid compound is named as 14,16-dihydroxy-diosgenin (14,16-diosgenin), and the invention also provides the preparation method of the compound and application of the compound in preparing medicaments for preventing and / or treating hyperlipemia, adiposis and cerebral apoplexy. The steroid compound has the functions of lowering blood fat, reducing organism total fat, resisting acute cerebral ischemia and the like, and provides the probability of developing a novel medicament for treating the hyperlipemia, adjusting body fat of adiposis patients and resisting the cerebral apoplexy.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a new steroid compound. The present invention also relates to the preparation method of the compound and the use of the compound in the preparation of medicines for preventing and / or treating hyperlipidemia, obesity and cerebral apoplexy. Background technique [0002] In the prior art, many documents disclose methods for isolating saponins from Ophiopogon japonicus and uses of the saponins. For example, CN 200610014213.5 disclosed "A Preparation Method of Ophiopogon japonicus Total Saponins", CN 200710024566.8 disclosed "Application of Ophiopogon japonicus Saponin D in the Preparation of Drugs Regulating Vascular Endothelial Cell Signal Transduction Gene", CN 200710024568.7 disclosed "Ophiopogon japonicus Application of saponin D in the preparation of gene medicine for regulating the apoptosis of vascular endothelial cells", CN 200710024567.2 published "Application...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00A61K31/58A61P3/06A61P9/10A61P3/04
Inventor 郑一敏胥秀英傅善权王琳琳曾品涛
Owner CHONGQING UNIV OF TECH
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