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Compound alpha-keto acid dispersible tablet and preparation method thereof

A technology of dispersible tablets and ketoacids, applied in the field of medicine

Inactive Publication Date: 2010-01-13
佟兵 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large part of chronic kidney disease eventually develops into end-stage uremia. Once it enters uremia, renal replacement therapy can only be used to maintain life, which will inevitably cause huge mental pressure and economic burden to patients, families and society

Method used

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  • Compound alpha-keto acid dispersible tablet and preparation method thereof
  • Compound alpha-keto acid dispersible tablet and preparation method thereof
  • Compound alpha-keto acid dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Compound α-ketoacid dispersible tablet of the present invention contains:

[0020] 1. Prescription of granules

[0021]

[0022]

[0023] 2. Prescription of excipients

[0024]

Embodiment 2

[0026] (1) α-racemic ketoisoleucine calcium, α-ketoleucine calcium, α-ketophenylalanine calcium, α-ketovaline calcium, α-racemic hydroxymethionine calcium, L- Lysine acetate, L-threonine, L-tryptophan, L-histidine, L-tyrosine passed through 80 mesh sieve for use; microcrystalline cellulose, cross-linked polyvinylpyrrolidone, carboxymethyl Sodium starch, orange essence, aspartame, micropowder silica gel and magnesium stearate are passed through an 80-mesh sieve for later use;

[0027] (2) Weigh α-racemic ketoisoleucine calcium, α-ketoleucine calcium, α-ketophenylalanine calcium, α-ketovaline calcium, α-racemic hydroxymethionine Calcium, L-lysine acetate, L-threonine, L-tryptophan, L-histidine, L-tyrosine, cross-linked polyvinylpyrrolidone, mix well, add absolute ethanol to make soft material, granulated through a 30-mesh sieve, dried at 50°C, and granulated through a 24-mesh sieve;

[0028] (3) Mix the above-mentioned granules with microcrystalline cellulose, cross-linked pol...

Embodiment 3

[0030] (1) α-racemic ketoisoleucine calcium, α-ketoleucine calcium, α-ketophenylalanine calcium, α-ketovaline calcium, α-racemic hydroxymethionine calcium, L- Lysine acetate, L-threonine, L-tryptophan, L-histidine, L-tyrosine passed through 80 mesh sieve for use; microcrystalline cellulose, cross-linked polyvinylpyrrolidone, carboxymethyl Sodium starch, orange essence, aspartame, micropowder silica gel and magnesium stearate are passed through an 80-mesh sieve for later use;

[0031] (2) Weigh α-racemic ketoisoleucine calcium, α-ketoleucine calcium, α-ketophenylalanine calcium, α-ketovaline calcium, α-racemic hydroxymethionine Calcium, L-lysine acetate, L-threonine, L-tryptophan, L-histidine, L-tyrosine, cross-linked polyvinylpyrrolidone, mix well, add absolute ethanol to make soft material, granulated through a 30-mesh sieve, dried at 45°C, and granulated through a 24-mesh sieve;

[0032] (3) Mix the above-mentioned granules with microcrystalline cellulose, cross-linked pol...

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Abstract

The invention discloses a compound alpha-keto acid dispersible tablet for treating chronic kidney diseases, containing four kinds of keto amino acid calcium, one kind of hydroxyamino acid calcium, five kinds of amino acid and pharmaceutically acceptable adjuvants. The tablet is mainly and clinically used for postponing renal failure process, correcting metabolic disturbance, coordinating with low-protein diet and preventing and treating damages caused by protein metabolism disorder because of chronic renal insufficiency.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound α-ketoacid dispersible tablet and a preparation method thereof. Background technique [0002] In recent years, the prevalence of chronic kidney disease has been increasing significantly around the world. In the United States alone, there are currently as many as 20 million people at risk of suffering from this disease. Although there is no exact epidemiological data in China, it is estimated from a single-sample study in Shanghai that there are about 18 million people with the disease. The high incidence of chronic kidney disease is closely related to the improvement of social industrialization, population aging, and the increase of the incidence of diseases that cause kidney damage, especially diabetes. A large part of chronic kidney disease eventually develops into end-stage uremia. Once it enters uremia, renal replacement therapy can only be used to ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/198A61K31/405A61K31/4172A61P13/12A61P3/00
Inventor 颜文革佟兵漆新国王立强于杨阚迎昕曹晓冬
Owner 佟兵
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