Traditional Chinese medicine composite for resisting tumor and adjusting immunity, preparation method thereof and application thereof in preparing medicine for resisting tumor and adjusting immunity

Abstract

The invention discloses a traditional Chinese medicine composite for resisting tumor and adjusting immunity, a preparation method thereof and application thereof in preparing medicament for resistingtumor and adjusting immunity. The traditional Chinese medicine composite consists of croton cream, balloon flower and the bulb of fritillary proportioning 1:3:3, and is characterized in that in the croton cream composition, content of croton oil accounts for 8-12% of the total weight of the croton cream, and content of crotonoside accounts for 1.47-5.59% of the total weight of the croton cream. The croton cream is prepared according to the following preparation method: separating and extracting croton oil from croton kernel to respectively obtain croton dreg and croton oil; then adding proportioned croton oil into croton dreg, and grinding evenly. The invention employs modern cell and molecular biology and other experiment means, overcomes defects of modern technologies, and effectively destructs toxalbumin in croton cream and adjusts content of croton oil when guaranteeing medicinal activity for efficacies of resisting tumor and adjusting immunity of the ancient prescription of threewhite medicinal powder, thus ensuring curative effect and having higher safety.

Description

technical field [0001] The invention relates to an anti-tumor and immunoregulatory traditional Chinese medicine composition, a preparation method thereof and its application in the preparation of anti-tumor and immune-regulatory medicines. Background technique [0002] Sanwubai San comes from the classical Chinese medical book "Treatise on Febrile Diseases". It is composed of croton cream, platycodon grandiflorum and Fritillaria in a ratio of 1:3:3. Due to the strong attacking power of Croton Cream in the prescription, the traditional processing technology of Croton Cream is not stable, and it is difficult to correspond to the current diseases in the cold and hard chest syndrome. . In recent years, we have completed research on this ancient prescription by completing projects such as the Natural Science Foundation of Jiangsu Provincial Department of Science and Technology (NO.BK2001129), the National Natural Science Foundation of China (NO.30572352) and the National Pharmac...

AI Technical Summary

Problems solved by technology

The problem with this method is that the operation is complicated, the content of croton oil is difficult to control during the segregation process, and the stability of the oil content of the croton cream generated is not enough. It is completely based on experience and difficult to grasp.

[0011] As can be seen from the above analysis, although there are problems in the traditional method of pressing and removing oil to make cream, it also ensures the concentration of other components of croton and the exertion of their effects while controlling the safe and effective concentration of croton oil. The disadvantage is that the concentration of croton oil The determination depends on experience, and the stability is not enough; the starch dilution method is convenient to prepare, saves labor and time, and saves medicinal materials, but it has the problem of diluting other medicinal ingredients, so it needs to be improved; the third frosting method has a better process idea , can accurately divide the dose, control the amount of oil, and solve the shortcomings of the traditional processing method, but it cannot jump out of the frame of the dilution method, but it is more accurate than the starch dilution method, and there are still the same problems as the dilution method

According to reports, although it is also prepared according to the starch dilution method of the Pharmacopoeia, the oil content of croton cream is uneven due to factors such as croton quality and personnel operation.

For example, the drug standard of Henan Province is determined to be 38-40%. [5] ; Another person determined 4 batches of croton cream, and its oil content was 18-42%. [6] , the gap is very large, so it is difficult to guarantee the stability of the actual oil content and clinical efficacy of croton cream

Images