Traditional Chinese medicine composite for resisting tumor and adjusting immunity, preparation method thereof and application thereof in preparing medicine for resisting tumor and adjusting immunity

An immune regulation and anti-tumor technology, which is applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulas, etc., can solve the problems of difficulty in grasping, difficult to ensure the oil content of croton cream and the stability of clinical curative effect, and insufficient stability

Inactive Publication Date: 2010-02-24
周春祥 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The problem with this method is that the operation is complicated, the content of croton oil is difficult to control during the segregation process, and the stability of the oil content of the croton cream generated is not enough. It is completely based on experience and difficult to grasp.
[0011] As can be seen from the above analysis, although there are problems in the traditional method of pressing and removing oil to make cream, it also ensures the concentration of other components of croton and the exertion of their effects while controlling the safe and effective concentration of croton oil. The disadvantage is that the concentration of croton oil The determination depends on experience, and the stability is not enough; the starch dilution method is convenient to prepare, saves labor and time, and saves medicinal materials, but it has the problem of diluting other medicinal ingredients, s

Method used

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  • Traditional Chinese medicine composite for resisting tumor and adjusting immunity, preparation method thereof and application thereof in preparing medicine for resisting tumor and adjusting immunity
  • Traditional Chinese medicine composite for resisting tumor and adjusting immunity, preparation method thereof and application thereof in preparing medicine for resisting tumor and adjusting immunity
  • Traditional Chinese medicine composite for resisting tumor and adjusting immunity, preparation method thereof and application thereof in preparing medicine for resisting tumor and adjusting immunity

Examples

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Effect test

Embodiment 1

[0127] Embodiment 1, anti-tumor and immunoregulatory Chinese medicine composition, and preparation method thereof: (1). First, the croton kernels are dried and pulverized in an oven; (2). The pulverized croton kernels are dissolved in petroleum ether with a low boiling point In; (3). Reflux then, separate the croton dregs and petroleum ether solution by methods such as suction filtration, i.e. the extract; (4). The croton dregs are refluxed again for extraction and suction filtration to obtain the final croton dregs and the extract; ( 5). The two extracts are combined to recover petroleum ether under reduced pressure to obtain croton oil, which is stored; (6). Finally, the croton dregs are dried at 105°C to destroy the toxic protein and evaporate the petroleum ether, and then crushed and sieved (7). Preparation of croton cream: first weigh a certain amount of croton oil with the above-mentioned croton oil and croton dregs obtained respectively, and then press the formula 10%=cr...

Embodiment 2

[0128] Embodiment 2 is substantially the same as Example 1, but has the following changes: in the described croton cream component, the content of croton oil is 10% of the croton cream gross weight. The content of crotonin is 1.47-5.59% of the total weight of the croton cream. The drying temperature of croton dregs is 100°C.

Embodiment 3

[0129] Embodiment 3 is substantially the same as Example 1, but has the following changes: in the described croton cream component, the content of croton oil is 8% of the croton cream gross weight. The drying temperature of croton dregs is 110°C.

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Abstract

The invention discloses a traditional Chinese medicine composite for resisting tumor and adjusting immunity, a preparation method thereof and application thereof in preparing medicament for resistingtumor and adjusting immunity. The traditional Chinese medicine composite consists of croton cream, balloon flower and the bulb of fritillary proportioning 1:3:3, and is characterized in that in the croton cream composition, content of croton oil accounts for 8-12% of the total weight of the croton cream, and content of crotonoside accounts for 1.47-5.59% of the total weight of the croton cream. The croton cream is prepared according to the following preparation method: separating and extracting croton oil from croton kernel to respectively obtain croton dreg and croton oil; then adding proportioned croton oil into croton dreg, and grinding evenly. The invention employs modern cell and molecular biology and other experiment means, overcomes defects of modern technologies, and effectively destructs toxalbumin in croton cream and adjusts content of croton oil when guaranteeing medicinal activity for efficacies of resisting tumor and adjusting immunity of the ancient prescription of threewhite medicinal powder, thus ensuring curative effect and having higher safety.

Description

technical field [0001] The invention relates to an anti-tumor and immunoregulatory traditional Chinese medicine composition, a preparation method thereof and its application in the preparation of anti-tumor and immune-regulatory medicines. Background technique [0002] Sanwubai San comes from the classical Chinese medical book "Treatise on Febrile Diseases". It is composed of croton cream, platycodon grandiflorum and Fritillaria in a ratio of 1:3:3. Due to the strong attacking power of Croton Cream in the prescription, the traditional processing technology of Croton Cream is not stable, and it is difficult to correspond to the current diseases in the cold and hard chest syndrome. . In recent years, we have completed research on this ancient prescription by completing projects such as the Natural Science Foundation of Jiangsu Provincial Department of Science and Technology (NO.BK2001129), the National Natural Science Foundation of China (NO.30572352) and the National Pharmac...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P37/02A61P35/00
CPCA61K36/8966A61K36/47A61K36/34A61P35/00A61P37/02A61K2300/00
Inventor 周春祥毛星原郭建国
Owner 周春祥
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