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A high-efficiency anti-tumor potassium sodium niobate-based piezoelectric material and its preparation method and application

A potassium sodium niobate-based, piezoelectric material technology, applied in the field of piezoelectric ceramics, can solve the problems of residual tumor cells at the edge, inconvenient to carry external electrical appliances, damage to healthy tissues and other side effects, and achieve a lead-free and pollution-free biological phase. Capacitive, improve piezoelectricity, good stability

Active Publication Date: 2021-07-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical treatment of cancer is to use surgery to directly remove the tumor lesion area, but it is easy to cause residual tumor cells at the edge, so not only implants are needed to fill the surgical site, but also auxiliary physical or chemical treatment is needed to kill the residual tumor cells. tumor cells
On the one hand, electrotherapy in physical therapy plays an important role in anti-tumor. It uses built-in electrodes to generate an electric field to kill tumors. However, because external electrical appliances are inconvenient to carry, inserting probes may cause secondary damage to patients.
On the other hand, drug treatment in chemotherapy also plays an irreplaceable role, but there are still big problems in drug dosage. Low dosage cannot completely cure the patient, but excessive drug dosage will damage the surrounding healthy tissues and cause other diseases. toxic side effects

Method used

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  • A high-efficiency anti-tumor potassium sodium niobate-based piezoelectric material and its preparation method and application
  • A high-efficiency anti-tumor potassium sodium niobate-based piezoelectric material and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0041] A preparation method of sodium selenite-doped potassium sodium niobate anti-tumor piezoelectric ceramic implant, comprising the following steps:

[0042] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 3% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0043](2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, then with binding ...

Embodiment 2

[0047] A preparation method of sodium selenite-doped potassium sodium niobate anti-tumor piezoelectric ceramic implant, comprising the following steps:

[0048] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 6% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0049] (2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, then with binding...

Embodiment 3

[0053] A preparation method of sodium selenite-doped potassium sodium niobate anti-tumor piezoelectric ceramic implant, comprising the following steps:

[0054] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 10% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0055] (2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, then with bindin...

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Abstract

The invention belongs to the technical field of medical anti-tumor materials, and discloses a high-efficiency anti-tumor potassium sodium niobate-based piezoelectric material and its preparation method and application. The application of the piezoelectric material in the preparation of medical anti-tumor materials, the preparation method of the material: 1) ball milling niobium pentoxide, potassium carbonate, sodium carbonate and doping element compounds to obtain ball milling powder; ball milling powder The body is calcined to obtain element-doped potassium sodium niobate-based ceramic powder; the doped element compound is a compound containing more than one element in selenium, zinc, iron, and molybdenum, or a compound containing selenium, a compound containing zinc, or a compound containing iron 1. More than one of the molybdenum-containing compounds; 2) uniformly mixing the element-doped potassium sodium niobate-based ceramic powder with a binder, granulating, forming, debinding, dense sintering, and polarization treatment to obtain a piezoelectric material. The piezoelectric material of the invention has good piezoelectricity, biocompatibility and stability, remarkable antitumor performance and long-acting antitumor effect.

Description

technical field [0001] The invention belongs to the technical field of anti-tumor implant materials, and specifically relates to a piezoelectric ceramic for dual-effect anti-tumor purposes by utilizing the piezoelectric properties of piezoelectric materials and anti-cancer elements released by the piezoelectric materials, and its preparation and application. The piezoelectric material of the invention is used for preparing anti-tumor materials, especially anti-tumor implant materials. Background technique [0002] At present, cancer, as one of the main causes of human death, has received widespread attention. The current clinical treatment of cancer is to use surgery to directly remove the tumor lesion area, but it is easy to cause residual tumor cells at the edge, so not only implants are needed to fill the surgical site, but also auxiliary physical or chemical treatment is needed to kill the residual tumor cells. tumor cells. On the one hand, electrotherapy in physical t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/495C04B35/622C04B35/63A61N1/05
CPCA61N1/05C04B35/495C04B35/622C04B35/6303C04B2235/3201C04B2235/3256C04B2235/3272C04B2235/3284C04B2235/38C04B2235/5427C04B2235/602C04B2235/656C04B2235/6567
Inventor 宁成云姚甜甜陈俊祺肖才榕王珍高张珂嘉胡诗迁
Owner SOUTH CHINA UNIV OF TECH
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