Efficient anti-tumor potassium-sodium niobate based piezoelectric material, as well as preparation method and application thereof

A potassium-sodium niobate-based, piezoelectric material technology, applied in the field of piezoelectric ceramics, can solve the problems of residual tumor cells at the edge, inconvenient carrying of external electrical appliances, side effects of damaging healthy tissues, etc., and achieves lead-free and pollution-free biophase Capacitance, improved piezoelectricity, and good stability

Active Publication Date: 2019-03-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical treatment of cancer is to use surgery to directly remove the tumor lesion area, but it is easy to cause residual tumor cells at the edge, so not only implants are needed to fill the surgical site, but also auxiliary physical or chemical treatment is needed to kill the residual tumor cells. tumor cells
On the one hand, electrotherapy in physical therapy plays an important role in anti-tumor. It uses built-in electrodes to generate an electric field to kill tumors. However, because external electrical appliances are inconvenient to carry, inserting probes may cause secondary damage to patients.
On the other hand, drug treatment in chemotherapy also plays an irreplaceable role, but there are still big problems in drug dosage. Low dosage cannot completely cure the patient, but excessive drug dosage will damage the surrounding healthy tissues and cause other diseases. toxic side effects

Method used

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  • Efficient anti-tumor potassium-sodium niobate based piezoelectric material, as well as preparation method and application thereof
  • Efficient anti-tumor potassium-sodium niobate based piezoelectric material, as well as preparation method and application thereof

Examples

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Embodiment 1

[0041] A preparation method of sodium selenite-doped potassium sodium niobate anti-tumor piezoelectric ceramic implant, comprising the following steps:

[0042] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 3% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0043](2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, then with binding ...

Embodiment 2

[0047] A preparation method of sodium selenite-doped potassium sodium niobate anti-tumor piezoelectric ceramic implant, comprising the following steps:

[0048] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 6% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0049] (2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, then with binding...

Embodiment 3

[0053] A preparation method of sodium selenite-doped potassium sodium niobate anti-tumor piezoelectric ceramic implant, comprising the following steps:

[0054] (1) Put absolute ethanol, niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite in a ball milling device for 8 hours at a speed of 300 rpm, let stand for 1 hour, dry at 60°C to constant weight, and calcinate at 750°C for 2 hours , be ground into powder, obtain sodium selenite doped potassium sodium niobate ceramic powder; Niobium pentoxide, potassium carbonate, sodium carbonate mass ratio 4:1:0.8; The consumption of sodium selenite is niobium pentoxide, 10% of the total mass of sodium carbonate and potassium carbonate; the ratio of the consumption of absolute ethanol to the total mass of niobium pentoxide, potassium carbonate, sodium carbonate and sodium selenite is 5mL:1g;

[0055] (2) Sodium selenite doped potassium sodium niobate ceramic powder is ground, cross 80 mesh sieves, then with bindin...

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Abstract

The invention belongs to the technical field of medical anti-tumor materials, and discloses an efficient anti-tumor potassium-sodium niobate based piezoelectric material, as well as a preparation method and application thereof. The piezoelectric material is applied in preparation of medical anti-tumor materials. The preparation method comprises the following steps: (1) performing ball-milling on niobium pentoxide, potassium carbonate, sodium carbonate and an element doped compound to obtain ball-milled powder; calcining the ball-milled powder to obtain element-doped potassium-sodium niobate based ceramic powder, wherein the element doped compound is more than one element of selenium, zinc, iron and molybdenum or more than one of a selenium-containing compound, a zinc-containing compound, an iron-containing compound and a molybdenum-containing compound; and (2) uniformly mixing the element-doped potassium-sodium niobate based ceramic powder with adhesive, granulating, forming, glue discharging and compact sintering, and polarizing to obtain the piezoelectric material. The piezoelectric material has excellent piezoelectric property, biocompatibility, stability and remarkable anti-tumor performance, and has a long-acting anti-tumor effect.

Description

technical field [0001] The invention belongs to the technical field of anti-tumor implant materials, and specifically relates to a piezoelectric ceramic for dual-effect anti-tumor purposes by utilizing the piezoelectric properties of piezoelectric materials and anti-cancer elements released by the piezoelectric materials, and its preparation and application. The piezoelectric material of the invention is used for preparing anti-tumor materials, especially anti-tumor implant materials. Background technique [0002] At present, cancer, as one of the main causes of human death, has received widespread attention. The current clinical treatment of cancer is to use surgery to directly remove the tumor lesion area, but it is easy to cause residual tumor cells at the edge, so not only implants are needed to fill the surgical site, but also auxiliary physical or chemical treatment is needed to kill the residual tumor cells. tumor cells. On the one hand, electrotherapy in physical t...

Claims

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Application Information

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IPC IPC(8): C04B35/495C04B35/622C04B35/63A61N1/05
CPCA61N1/05C04B35/495C04B35/622C04B35/6303C04B2235/3201C04B2235/3256C04B2235/3272C04B2235/3284C04B2235/38C04B2235/5427C04B2235/602C04B2235/656C04B2235/6567
Inventor 宁成云姚甜甜陈俊祺肖才榕王珍高张珂嘉胡诗迁
Owner SOUTH CHINA UNIV OF TECH
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