Metformin acidic double salt compound and preparation method

Abstract

The invention provides a metformin acidic double salt, which is prepared by the following steps: mixing metformin and H2Y or MHR for reaction; concentrating; adding a weak polar solvent for crystallization; and filtering and drying. The metformin acidic double salt has the characteristics of good stability and improvement on bioavailability, and is converted into metformin in vivo so as to achieve the aim of killing cancer stem cells. The metformin acidic double salt can be used with other anti-tumor chemotherapy medicines to achieve better treatment effect. The structural general formula of the metformin acidic double salt is shown as follows.

Description

technical field The invention belongs to the technical field of chemical industry and pharmacy, and relates to a metformin acid double salt compound and a preparation method thereof. The metformin acid double salt of the present invention has the characteristics of good stability and improved bioavailability, and is converted into metformin in the body, so as to achieve the purpose of killing cancer stem cells, and is used in combination with other chemotherapeutic drugs for the treatment of cancer. Treatment, recurrence and metastasis. technical background The structural formula of metformin (Guanfacine) is as follows: The clinical application is metformin hydrochloride (Metformin Hydrochloride), the chemical name is 1,1-dimethylbiguanide hydrochloride. The pharmacological action is that metformin hydrochloride is a hypoglycemic drug, which can improve the blood sugar tolerance of patients with type 2 diabetes and reduce the basal and postprandial blood sugar. The mec...

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Problems solved by technology

It shows that the combined drug can also quickly reduce the tumor mass and prevent the deterioration for a long time, but the use of doxorubicin alone cannot prevent the recurrence and metastasis of cancer