Method for extracting and separating eugenol, pharmaceutical composition containing eugenol and preparation method thereof

A separation method and eugenol technology are applied in the field of pharmaceutical compositions containing eugenol and preparation thereof, and can solve the problems of inappropriate use of morphine, ineffectiveness of intestinal paralysis, imbalance of balance and the like, and achieve reduction of intestinal obstruction and remarkable therapeutic effect. , the effect of stable nature

Inactive Publication Date: 2013-08-21
王永清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. Intestinal obstruction is caused by intestinal paralysis, while domperidone is effective in promoting gastric emptying, and basically has no effect on intestinal paralysis
[0004] 2. Scopolamine mixed anesthesia is often used during surgery. After using scopolamine, morphine should not be used
[0006] 4. Adverse reactions of morphine: blood in the stool, asthma, imbalance, convulsions
[0007] At present, there is a lack of suitable drugs on the market for accelerating the recovery of gastrointestinal function after abdominal surgery, and there is even a lack of a new class of traditional Chinese medicine for accelerating the recovery of gastrointestinal function after abdominal surgery and avoiding or reducing intestinal obstruction.

Method used

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  • Method for extracting and separating eugenol, pharmaceutical composition containing eugenol and preparation method thereof

Examples

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Effect test

preparation example Construction

[0038] A preparation method containing eugenol pharmaceutical composition, the method comprises the following steps:

[0039] 1) Weigh eugenol, soybean lecithin, glycerin, distilled water, and chlorhexidine acetate respectively according to the above ratio;

[0040] 2) Take eugenol, add soybean lecithin, stir to mix and dissolve;

[0041] 3) Dissolve chlorhexidine acetate in an appropriate amount of 95% ethanol;

[0042] 4) Take glycerin, add chlorhexidine acetate ethanol solution and mix well;

[0043] 5) Take the above eugenol and soybean lecithin solution, add glycerin and chlorhexidine acetate solution under stirring at 25±2°C, and titrate to the end point with distilled water;

[0044] 6) Sterilize, subpackage and pack after passing the inspection according to the standard of this product.

[0045]The pharmaceutical composition provided by the present invention is divided into two groups when carrying out comparative clinical experiment, and every group of 120 people o...

Embodiment 1

[0046] Example 1, the control group, use 12g of fried radish, 9g of rhubarb, 6g of woody fragrance, 500g of table salt, grind into powder, apply to the navel, 2-4g each time (for Shenjue point, once every 6 hours), use Those who were ineffective for 3 times were transferred to surgical treatment, and the recovery time of bowel sounds and anal exhaust time after abdominal operation were observed. As a result, among 120 cases, 32 cases recovered bowel sounds within 4 hours and anal exhaust within 5 hours after taking the medicine once, and the effective rate was 26.6%. In 23 cases, the effective rate was 19.2%. After 3 times of medication, bowel sounds recovered within 15 hours, and 14 cases had anal exhaust within 16 hours, with an effective rate of 11.6%. The total effective rate of three times of medication was 57.5%.

Embodiment 2

[0047] Example 2: In the treatment group, use eugenol nanoemulsion equivalent to 0.2 grams of eugenol each time (medicine at Shenjue point, once every 6 hours), and use 3 times of ineffective patients to switch to surgical treatment, and observe bowel sounds after abdominal surgery Recovery time, anal exhaust time, results, among the 120 cases, the bowel sounds recovered within 3 hours after taking the medicine once, and 95 cases had the anal exhaust within 4 hours, the effective rate was 79.2%. After taking the medicine twice, the bowel sounds recovered within 8 hours Sound recovery and anal exhaust occurred in 18 cases, and the effective rate was 15.0%. After 3 times of medication, bowel sounds recovered within 14 hours, and anal exhaust occurred in 3 cases, the effective rate was 2.5%, and the total effective rate was 96.6%.

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Abstract

The invention provides a method for extracting and separating eugenol, a pharmaceutical composition containing eugenol and a preparation method thereof. The method for extracting and separating eugenol comprises the following steps: (1) removing impurity and sieving out ashes for later use; (2) putting the clove obtained in step 1 in a beater, separately adding fourfold, triple and doubled 3% sodium hydroxide solution in sequence and respectively beating for 3 minutes, and suction filtering; (3) adding acid to the sodium hydroxide solution obtained in the step 2 so as to regulate to pH5, then adding sodium chloride to the sodium hydroxide solution obtained in step 2, wherein the addition of the sodium chloride accounts for 5 percent of the sodium hydroxide solution, allowing to stand overnight at the temperature of 3-6 DEG C, and respectively taking essential oil; (4) and vacuum distilling and separating Hg of 10mm at the temperature of 124 DEG C, finally obtaining eugenol. The invention provides a method for extracting and separating eugenol which is an effective component of clove and can be used for quickening the recovery of postoperative abdomen stomach function so as to avoid or reduce postoperative intestinal obstruction, a pharmaceutical composition containing eugenol and a preparation method thereof.

Description

technical field [0001] The invention relates to an extraction and separation method of eugenol, an active component of cloves, used for accelerating the recovery of gastrointestinal function after abdominal surgery and avoiding or reducing postoperative intestinal obstruction, a pharmaceutical composition containing eugenol and a preparation method thereof. Background technique [0002] If intestinal obstruction has developed after abdominal surgery, reoperation is required to solve the obstruction problem. However, severe infection has already occurred at the time of the obstruction, which brings great difficulties to the operation. In order to solve the inflammation problem, it takes a long time. Intestinal obstruction is a kind of emergency, and there are serious problems such as obstruction and inflammation at the same time, the two are incompatible with each other, and the fatality rate is high. According to reports, the mortality rate of intestinal obstruction after ab...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C07C43/23C07C41/34A61K31/085A61P1/14
Inventor王永清
Owner王永清