Intermediate of flavonoid compound and preparation method and application thereof

A technology of flavonoids and compounds, applied in sugar derivatives, organic chemistry, drug combination, etc., can solve the problems of complex and cumbersome separation and extraction of compounds of formula A, difficult to meet research applications, and low extraction efficiency
CN101712705AInactive Publication Date: 2010-05-26SHANGHAI INST OF PHARMA IND CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF PHARMA IND CO LTD
Publication Date
2010-05-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an intermediate of a flavonoid compound shown in a formula K and a preparation method thereof. In the heterogeneous solution of a non-protonic solvent and water, under the action of an alkaline reagent and a phase transfer catalyst, the compound shown in the formula L reacts with 2,3,4,6-tetraphenyl formyloxy bromo-glucose shown in the formula H, wherein R1 is -CO(CH2)nCH3 or benzoyl; n ranges from 0 to 8; and Bz is the benzoyl. The invention also relates to application of the intermediate of the flavonoid compound shown in the formula K in preparation of the flavonoid compound shown in the formula A. Compared with the conventional method for separating and extracting the flavonoid compound shown in the formula A from the plant, the method for preparing the flavonoid compound shown in the formula A from the intermediate of the flavonoid compound shown in the formula K can realize large-scale industrialized production, and has the advantages of simple steps, no special reagent or harsh requirements on reaction conditions, and high yield and purity.
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Description

technical field

[0001] The invention relates to a class of flavonoid compound intermediates and a preparation method and application thereof. Background technique

[0002] Common ischemic diseases include coronary heart disease, cerebral insufficiency, cerebral infarction and other heart and cerebrovascular ischemic diseases, which are one of the main diseases that endanger human health. Ischemic cerebrovascular diseases account for 50-70% of all cerebrovascular diseases, and are characterized by high morbidity, high mortality and high disability rate. health.

[0003] Apigenin 7-O-β-D-glucoside-4`-O-α-L-rhamnoside (Formula A) (English name: apigenin-7-O-β-D-glucopyranosyl-4`-O- α-L-rhamnopyranosid) is a flavonoid compound, which can be extracted and isolated from Ranunculus genus plants, such as Ranunculus sieboldii and R. sceleratus, and has certain anti-tumor, anti-HBV and The role of HSV-1. (Pan Yunxue, Study on the Chemical Constituents of Ranunculus chinensis, Chine...

Claims

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