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Animal pancreatic extract for preventing and curing diabetes

An extract and diabetes technology, which can be used in metabolic diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of lack of protection, small toxic and side effects, etc.

Inactive Publication Date: 2010-06-02
陈光明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of drugs that protect pancreatic β-cells, promote β-cell regeneration and repair, delay or reverse the severity of diabetes, and have less toxic side effects

Method used

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  • Animal pancreatic extract for preventing and curing diabetes
  • Animal pancreatic extract for preventing and curing diabetes
  • Animal pancreatic extract for preventing and curing diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Extraction and identification of small-molecule polypeptides from piglet pancreas

[0024] 1. Raw materials

[0025] Animals: Hybrid pigs, about 20 weeks old, slaughtered in legal slaughterhouses, with animal product quarantine certificates. The collection and transportation of raw materials are all processed at a low temperature of 20-25°C.

[0026] 2. Pancreas quality control:

[0027] 2.1 Weight: The average weight of a whole piglet pancreas (with a small amount of fat tissue) is 120±30 grams.

[0028] 2.2 Appearance and traits: the surface of the pancreas is smooth, fresh in color, off-white, with no peculiar smell, no wrapped nodules, and no abnormalities in the section.

[0029] 2.3 Determination of volatile basic nitrogen: Randomly select porcine pancreas at a ratio of 1%, cut out 10g of each pancreas, and carry out limit detection according to the national standard GB / TS009.44-2003 micro-diffusion method for checking volatile basic nitrogen, which ...

Embodiment 2

[0037] Example 2: Effect of the animal pancreas extract of the present invention on animal models of diabetes

[0038] 1. Modeling of diabetes in rats

[0039] Materials: Wistar rats, male, 200±10g, purchased from the Experimental Animal Center of Southern Medical University

[0040] Reagents and equipment: Streptozotocin (STZ, Sunland Company, USA); micro blood glucose meter (5D-2 type, Beijing Yicheng Bioelectronic Technology Co., Ltd.); animal weighing electronic balance (G&G, USA).

[0041] Methods: Receive qualified Wistar rats, after one week of adaptive feeding, fast overnight, intraperitoneally inject STZ (30mg / kg) on ​​an empty stomach to make models (method reference: Li Cai, editor-in-chief, replication of animal models of human diseases, People's Health Publishing Society, 2008 first edition; Diabetic animal models, p345.). One week after STZ injection, random blood glucose was detected, and those over 16.7mmol / L were selected as diabetic rats. Diabetic rats witho...

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Abstract

The invention relates to an animal pancreatic extract and a medicinal purpose of the animal pancreatic extract. In the invention, the animal pancreatic extract for preventing and curing diabetes is an active substance solution which is extracted from the fresh pancreas of a young pig and has small molecular weight not more than 10000 Daltons, the extraction liquid is supernatant liquid, the pH value of which is 6.0-7.0, and each 1ml of the extraction liquid contains not less than 15mg of polypeptide and does not contain insulin. The animal pancreatic extract of the invention is an active polypeptide substance with small molecular weight, which is obtained by taking the organ pancreas which causes the diabetes as a target spot, selecting the animal pancreas as a raw material and using the modern technology for extracting. The animal pancreatic extract of the invention is suitable for preventing and curing various types of diabetes, curing severe diabetes, preventing levis diabetes fromworsening, preventing organ posttransplantation diabetes, reducing adverse reaction of anti-rejection drugs, reversing or delaying the occurrence and the development of the severe diabetes, and preventing various complications of diabetes.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to an animal pancreas extract and the medicinal application of the animal pancreas extract. Background technique [0002] Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels. Diabetes has become a major disease affecting the physical and mental health of Chinese people due to its characteristics of great harm, difficult cure and high cost. The predisposing factors of diabetes include heredity, viral infection, autoimmunity, organ transplantation, dietary factors, negative emotions and so on. [0003] The incidence of diabetes is getting higher and higher. At present, there are about 180 million diabetic patients in the world. Experts predict that it will exceed 300 million by 2025, of which 75% are in developing countries such as India and China. According to statistics, the incidence rate of diabetes in the world is 3% to 5%, and the per capita inci...

Claims

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Application Information

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IPC IPC(8): A61K35/39A61P3/10
Inventor 陈光明王洪敏饶桂荣张海松杨富强莫国玉
Owner 陈光明
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