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Agomelatine-containing medicinal composition

A technology of agomelatine and composition, applied in the field of agomelatine preparation and preparation thereof, can solve the problems such as inability to use the preparation for industrial production, high price, no legal source and the like

Active Publication Date: 2012-01-25
万全万特制药江苏有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN03802710.0 discloses the and other excipients, It is a new compound made of 15% corn starch and 85% lactose monohydrate through spray drying-coagulation. This excipient needs to be imported, which is expensive and difficult to obtain relevant legal qualifications. There is no legal source and cannot be used in preparations Industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Ingredients

[0014] Mix Agomelatine, lactose, starch, and 50% sodium starch glycolate in equal amounts, add appropriate amount of starch slurry to moisten, make soft materials, granulate, dry, and size, add 50% sodium starch glycolate And magnesium stearate can be obtained by pressing.

Embodiment 2

[0016] Ingredients

[0017] Mix Agomelatine, lactose, starch, and 50% sodium starch glycolate in equal amounts, add appropriate amount of starch slurry to moisten, make soft materials, granulate, dry, and size, add 50% sodium starch glycolate And magnesium stearate can be obtained by pressing.

Embodiment 3

[0019] Ingredients

[0020] Mix Agomelatine, lactose, starch, and 50% sodium starch glycolate in equal amounts, add appropriate amount of starch slurry to moisten, make soft materials, granulate, dry, and size, add 50% sodium starch glycolate And magnesium stearate can be obtained by pressing.

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PUM

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Abstract

The invention provides an agomelatine-containing medicinal composition, which not only solves the problem of the dissolution of agomelatine in different crystal forms, but also meets the requirements of preparations for prescriptions and processes. The composition has the advantages of simple preparation process, convenience for operation, transport and storage, wide application range and suitability for large-scale production.

Description

Technical field [0001] A pharmaceutical composition containing agomelatine, in particular to a preparation of agomelatine and a preparation method thereof. Background technique [0002] Agomelatine is a selective agonist of melatonergic receptors on the one hand, and an antagonist of 5-HT2C receptors on the other. It is active in the treatment of severe depression, seasonal depression, sleep disorders, cardiovascular diseases, digestive diseases, insomnia, and fatigue caused by jet lag, appetite disturbances and obesity. [0003] European patent EP 0447285 discloses the preparation method of agomelatine and its therapeutic effect. [0004] Chinese patent CN03802710.0, which discloses And other excipients, It is a new type of compound made from 15% corn starch and 85% lactose monohydrate through spray drying-aggregation. The excipients need to be imported, which is expensive and difficult to obtain relevant legal qualifications. There is no legal source and cannot be used in prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61P25/24A61P25/20A61P9/00A61P1/00A61P3/04
Inventor 刘海丽张晓
Owner 万全万特制药江苏有限公司
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