Medicinal use of leonurine

Abstract

The invention relates to medicinal use of leonurine, and in particular provides use of leonurine and pharmaceutical salts thereof for improving estradiol (E2) level of human being or mammals or reducing luteinizing hormone (LH) or follicle stimulating hormone (FSH) level of the human being or the mammals. The novel use of the leonurine is beneficial to clinical practice and therapeutic effectiveness of mifepristone and misoprostol on the early pregnancy before artificial abortion, particularly to the treatment of the incomplete womb restoration after parturition or bleeding after medical abortion.

Description

Technical field: [0001] The invention belongs to the field of medicine and relates to a new medical application of motherwortine. Specifically, the present invention provides a new application of motherwortine for increasing human or mammalian estradiol (E2) levels or reducing human or mammalian luteinizing hormone (LH) or follicle stimulating hormone (FSH) levels. Background technique: [0002] Motherwort is the fresh or dry aerial part of Leonurus helerophyllus sweet, a plant of Labiatae, which is a traditional Chinese medicine. It has been recorded in past dynasties that it has the effects of invigorating blood circulation, regulating menstruation, dispelling blood stasis and promoting regeneration, diuresis and detumescence. Indications for irregular menstruation, metrorrhagia, dystocia, dysmenorrhea, postpartum stasis and other diseases, known as the "holy medicine of the blood family" and "good medicine for labor". It is known as the "sacred medicine for blood" and "...

AI Technical Summary

Problems solved by technology

[0003] Leonurine is one of the active substances of Motherwort. It only contains less than 5‰ in the crude drug, and the extraction process is relatively complicated. It is not only difficult to obtain a sufficient amount of product to meet the needs of production and life through the method of bio-enrichment, but also may be in the interest. Driven to cause immeasurable damage to associated creatures

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