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Medicinal composition containing trandolapril taste-masking composition

A trandolapril and composition technology, which is applied in the field of pharmaceutical compositions containing trandolapril taste-masking compositions, can solve the problems of decreased plasma concentration and increased plasma renin activity, achieves rapid disintegration, overcomes irritation and the like Sexual taste, simple operation effect

Active Publication Date: 2012-11-07
河南比福制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking ramipril can lead to an increase in plasma renin activity and a decrease in plasma concentrations of angiotensin II and aldosterone

Method used

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  • Medicinal composition containing trandolapril taste-masking composition
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  • Medicinal composition containing trandolapril taste-masking composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] (1) Preparation of trandolapril taste-masking composition

[0147] Trandolapril 1g

[0148] Mannitol 20g

[0149] Gelatin 20g

[0150] Aspartame 0.1g

[0151] Makes 1000 pieces

[0152] Preparation process: Pass the gelatin, mannitol and aspartame through a 60-mesh sieve, add an appropriate amount of distilled water to the gelatin to dissolve the gelatin, add trandolapril, mannitol and aspartame under stirring, and place at 70-80 Stir in a water bath at ℃, evaporate to dryness, pulverize, pass through a 50-mesh sieve, and set aside;

[0153] (2) Preparation of Trandolapril Orally Disintegrating Tablets

[0154] Trandolapril Masking Composition 41.1g

[0155] Microcrystalline Cellulose 6.2g

[0156] Cross-linked polyvinylpyrrolidone 3.6g

[0157] Magnesium stearate 0.5g

[0158] Makes 1000 pieces

[0159] Preparation process: double-checked and weighed according to the amount of the above-mentioned auxiliary materials, mixed evenly, and pressed into tablets wit...

Embodiment 2

[0161] (1) Preparation of trandolapril taste-masking composition

[0162] Trandolapril 2g

[0163] Mannitol 40g

[0164] Gelatin 40g

[0165] Aspartame 0.2g

[0166] Makes 1000 pieces

[0167] Preparation process: Pass the gelatin, mannitol and aspartame through a 60-mesh sieve, add an appropriate amount of distilled water to the gelatin to dissolve the gelatin, add trandolapril, mannitol and aspartame under stirring, and place at 70-80 Stir in a water bath at ℃, evaporate to dryness, pulverize, pass through a 50-mesh sieve, and set aside;

[0168] (2) Preparation of Trandolapril Orally Disintegrating Tablets

[0169] Trandolapril Masking Composition 82.2g

[0170] Microcrystalline Cellulose 12.3g

[0171] Cross-linked polyvinylpyrrolidone 7.2g

[0172] Magnesium Stearate 1.0g

[0173] Makes 1000 pieces

[0174] Preparation process: according to the amount of the above-mentioned raw and auxiliary materials, double-checked and weighed, mixed evenly, pressed into table...

Embodiment 3

[0176] (1) Preparation of trandolapril taste-masking composition

[0177] Trandolapril 4g

[0178] Mannitol 80g

[0179] Gelatin 80g

[0180] Aspartame 0.4g

[0181] Makes 1000 pieces

[0182] Preparation process: Pass the gelatin, mannitol and aspartame through a 60-mesh sieve, add an appropriate amount of distilled water to the gelatin to dissolve the gelatin, add trandolapril, mannitol and aspartame under stirring, and place at 70-80 Stir in a water bath at ℃, evaporate to dryness, pulverize, pass through a 50-mesh sieve, and set aside;

[0183] (2) Preparation of Trandolapril Orally Disintegrating Tablets

[0184] Trandolapril Masking Composition 164.4g

[0185] Microcrystalline Cellulose 24.7g

[0186] Cross-linked polyvinylpyrrolidone 14.4g

[0187] Magnesium Stearate 2.0g

[0188] Makes 1000 pieces

[0189] Preparation process: according to the amount of the above-mentioned raw and auxiliary materials, double-checked and weighed, mixed evenly, pressed into tab...

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Abstract

The invention relates to a medicinal composition containing trandolapril taste-masking composition and a preparation technique thereof. The medicinal composition has the following characteristics that: flavoring agent in the trandolapril taste-masking composition is selected from gelatin, mannitol and aspartame, the medicinal composition is in the form of powder or particles, consequently, the stability of preparation is good, bitter taste is masked, taste is good, disintegration is quick, absorption is quick, and carrying is convenient.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing trandolapril taste-masking composition and a preparation method thereof. The trandolapril is prepared as a taste-masking composition to mask the oral irritation of the trandolapril. Background technique [0002] Hypertension is one of the diseases with the largest number of patients in my country. At present, the number of patients in China has exceeded 150 million, accounting for 11% of the total population. Hypertensive patients must take medicine for life, and insist on taking it every day. With the development of population aging trend, the increasing pressure of social competition on human health, the surge of obese and hyperlipidemia population, the number of hypertensive patients will reach an unprecedented number. my country's antihypertensive drug market has also been on the rise in the past few years. According to the statistics of relevant departments, in 2003, the total domes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/05A61K47/42
Inventor 严洁黄欣
Owner 河南比福制药股份有限公司
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