Magnetic immuno-chromatographic test paper strip for quantitatively detecting tumor associated antigen 15-3 in blood and preparation method thereof

CN101762697AInactive Publication Date: 2010-06-30CHEMCLIN DIAGNOSTICS CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHEMCLIN DIAGNOSTICS CO LTD
Publication Date
2010-06-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a magnetic immuno-chromatographic test paper strip for quantitatively detecting tumor associated antigen 15-3 in blood and a preparation method thereof. A coating film, a magnet particle pad combined with tumor associated antigen 15-3 antibodies, a sample pad and a water absorbing pad are sequentially and alternately stuck on a base plate in a staggering way at intervals of 2mm, and then the upper layer is covered by a transparent plastic sealing film to form a test paper strip. A tumor associated antigen 15-3 antibody detection line and a quality control line are pre-coated on the coating film. The invention introduces the magnetic immuno-chromatographic technology into the quantitative detection of tumor associated antigen 15-3, and has the advantages that the detection sensitivity is greatly improved, the accurate quantitative results can be given, the operation is simple and convenient and the diagnosis is rapid.
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Description

technical field

[0001] The invention belongs to the field of medical testing, in particular to a magnetic immunochromatographic test strip for quantitatively detecting tumor-associated antigen 15-3 in blood and a preparation method thereof. Background technique

[0002] In 1984, Hilkens et al. made a mouse monoclonal antibody (115-DB) from the glycoprotein MAM-6 on the human milk fat globule membrane. In 1984, Kufu et al. made a monoclonal antibody (DF-3) from the liver metastatic breast cancer cell membrane. CA15-3 is a breast cancer-associated antigen, a glycoprotein with a molecular weight of more than 400kD. Patients with breast cancer often have elevated CA15-3, but the sensitivity is low in the early stage of breast cancer, and the positive rate of metastatic breast cancer can reach 80%. CA15-3 can be used as an auxiliary diagnostic indicator for primary breast cancer, and can also be used as an indicator for follow-up after surgery to monitor tumor recurrence and met...

Claims

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