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Method for determining clonidine hydrochloride content in Zhenju Jiangya Tablet

A technology of clonidine hydrochloride and Zhenju Jiangya Tablets, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of poor detection reproducibility and large differences, so as to improve reproducibility, reliable test results, and control products quality effect

Active Publication Date: 2010-07-21
ZHONGXING PHARM CO LTD JIANGSU
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Problems solved by technology

[0003] Dichloromethane was used in the existing method for detecting the content of clonidine hydrochloride in Zhenju Jiangya Tablets, and the detection reproducibility was poor. The same dichloromethane produced by Shanghai Chemical Reagent Factory and Nanjing Chemical Reagent Factory was used to do When testing, there is a large difference between the two

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  • Method for determining clonidine hydrochloride content in Zhenju Jiangya Tablet

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Embodiment Construction

[0013] The present invention will be further described by the following examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0014] A kind of assay method of clonidine hydrochloride content in Zhenju Jiangya tablet of the present invention, the method comprises the steps:

[0015] 1) Preparation of reference substance solution: get an appropriate amount of clonidine hydrochloride reference substance, accurately weighed, add mobile phase to make a solution containing 10 μg per ml, to obtain the reference substance solution;

[0016] 2) Preparation of the test solution: take 10 tablets of this product, remove the film coat, accurately weigh, grind finely, and accurately weigh an appropriate amount, which is equivalent to 120 μg of clonidine hydrochloride, put it in a 50ml volumetric flask, and add a pH value of 4.0 40ml of citric acid-disodium hydrogen phosphate...

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Abstract

The invention discloses a method for determining clonidine hydrochloride content in a Zhenju Jiangya Tablet, which comprises the following steps that: a reference substance solution is prepared; a sample solution is specially prepared; finally high performance liquid chromatography is used to determine; octadecyl silane bonded silica serves as the filler; methanol and 0.01mol / L sodium dihydrogen phosphate in the volume ratio of 30:70 is mobile phase; the detection wavelength is 210nm; the flowing speed is 1.0ml / min; calculated by the clonidine hydrochloride peak, the theoretical plate number is no less than 2000; and when in determination, respective 20mu l of the reference substance solution and the sample solution are precisely absorbed, a liquid chromatograph is injected, and the content of clonidine hydrochloride is determined. The method specially prepares the sample, and then uses the high performance liquid chromatography to determine the clonidine hydrochloride content in the Zhenju Jiangya Tablet, can improve the reoccurrence, and meanwhile, the inspection results are more reliable, and the product quality can be better controlled.

Description

technical field [0001] The invention relates to a method for detecting medicines, in particular to a method for determining the content of clonidine hydrochloride in Zhenju Jiangya Tablets. Background technique [0002] Zhenju Jiangya Tablet is a film-coated tablet, which turns yellowish-brown after removing the coating; tastes bitter; it is a compound preparation of Chinese and Western medicines, with multiple ingredients and synergistic effects. The dosage of western medicine components is small, safe and effective, and does not contain reserpine ; Functions and indications: for hypertension. Zhenju Jiangya Tablets are composed of wild chrysanthemum, nacre powder, rutin three traditional Chinese medicines and two western medicines, clonidine hydrochloride and hydrochlorothiazide. Nourishing yin and calming the wind, calming the nerves, rutin can dilate blood vessels and improve vascular permeability, clonidine hydrochloride, a western medicine ingredient, is a central α2 ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 武俊明张红梅
Owner ZHONGXING PHARM CO LTD JIANGSU
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