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Lidocaine and chlorhexidine aerosol

A lidocaine and aerosol technology, applied in the field of lidocaine-containing sprays, can solve problems such as easy to be wiped off by clothes, details are not reported, and frequent use is required to achieve less skin irritation and improve curative effect , good film-forming effect

Active Publication Date: 2010-07-28
江苏天济药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese herbal medicines are usually slow to take effect, and most of the finished products are tan, which is easy to color the skin; although western medicines are quick to take effect, they often cause some people to have side effects such as allergies, pimples, itching, etc. Wipe off, not waterproof
[0007] At present, there are Lidocaine and Chlorhexidine aerosol medicines on the market. The manufacturers include Shandong Dongwei, Jinan Weimin, etc., but only disclose three ingredients: lidocaine, chlorhexidine acetate, and benzalkonium bromide. The specific details of other excipients and propellants have not been reported

Method used

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  • Lidocaine and chlorhexidine aerosol
  • Lidocaine and chlorhexidine aerosol
  • Lidocaine and chlorhexidine aerosol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The consumption of each component is:

[0040] Lidocaine 20g

[0041] Chlorhexidine acetate 5g

[0042] Benzalkonium Bromide 1g

[0043] Vinylpyrrolidone-vinyl acetate copolymer 110g

[0044] Ethyl acetate 334g

[0045] Ethanol 310g

[0046] Propane 220g

[0047] Lidocaine, chlorhexidine acetate, benzalkonium bromide, vinylpyrrolidone-vinyl acetate copolymer, ethyl acetate and ethanol in the prescription amount of the present invention are fully stirred and evenly filtered, filled into spray aluminum cans, sealed Connect the spray pump, press into the propellant propylene butane, that is.

Embodiment 2

[0049] Lidocaine 20g

[0050] Chlorhexidine acetate 5g

[0051] Benzalkonium Bromide 1g

[0052] Vinylpyrrolidone-vinyl acetate copolymer 100g

[0053] Ethyl acetate 300g

[0054] Ethanol 330g

[0055] Propane 244g

[0056]Lidocaine, chlorhexidine acetate, benzalkonium bromide, vinylpyrrolidone-vinyl acetate copolymer, ethyl acetate and ethanol in the prescription amount of the present invention are fully stirred and evenly filtered, filled into spray aluminum cans, sealed Connect the spray pump, press into the propellant propylene butane, that is.

Embodiment 3

[0058] Lidocaine 20g

[0059] Chlorhexidine acetate 5g

[0060] Benzalkonium Bromide 1g

[0061] Vinylpyrrolidone-vinyl acetate copolymer 120g

[0062] Ethyl acetate 320g

[0063] Ethanol 310g

[0064] Propane 224g

[0065] Lidocaine, chlorhexidine acetate, benzalkonium bromide, vinylpyrrolidone-vinyl acetate copolymer, ethyl acetate and ethanol in the prescription amount of the present invention are fully stirred and evenly filtered, filled into spray aluminum cans, sealed Connect the spray pump, press into the propellant propylene butane, that is.

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PUM

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Abstract

In order to overcome the defects of current medicines for treating mosquito / bug bite, skin abrasion, soft tissue injury and minor burn, shorten treatment period, reduce adverse reaction, achieve convenient carrying, enhance curative effect and lower the use amount of medicine, the invention obtains a novel Lidocaine aerosol after optimized screening, which contains Lidocaine, chlorhexidine acetate, benzalkonium bromide, vinyl pyrrolidone-vinyl acetate copolymer, acetic ester, ethanol and propellant. The aerosol plays a good role of treating mosquito / bug bite and skin injury and simultaneously reduces the stimulation on skin.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a spray containing lidocaine. Background technique [0002] Mosquitoes are rampant in summer, and the exposed skin is easily bitten by mosquitoes. Mosquitoes belong to the order Insecta Diptera and are small insects. Inflammation, dengue fever and other infectious diseases, the mosquito's beak pierces the skin and there is a tingling sensation, and edematous erythema, papules or wheals may appear at the puncture site, and there is a large dark red petechiae in the center of the lesion. Complete depigmentation, characterized by pale circles around the sore point. The rash subsides on its own within 2 to 3 days, and the degree of rash reaction varies from person to person. Some people may have no symptoms after being bitten, and some may only have mild itching and slight pain, but some people with allergies may have obvious redness and swelling , even large ecchymosis, ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/155A61K31/14A61K47/32A61K47/14A61K47/10A61K47/06A61K9/12A61P17/04A61P17/02A61P17/00A61P31/00
Inventor 曹龙祥董自波邵建国
Owner 江苏天济药业有限公司
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