Porphyrin modified by diethylenetriamine pentaacetic acid gadolinium and preparation method and application thereof

Abstract

The invention discloses porphyrin modified by diethylenetriamine pentaacetic acid gadolinium and a preparation method and application thereof. The porphyrin modified by diethylenetriamine pentaacetic acid gadolinium has the following structure (I) shown in the specification of the invention. The porphyrin modified by diethylenetriamine pentaacetic acid gadolinium has favorable water solubility and higher biomagnetic effect. Through large quantity of grope by the inventor, the orphyrin modified by diethylenetriamine pentaacetic acid gadolinium has high enhancement in clinical MRI (Magnetic Resonance Imaging) and also stronger fluorescence quantum yield, strong fluorescent effect and wide application prospect and can be applied to the fields of nonlinear photoelectric materials, magnetic resonance imaging diagnosis, fluorescent molecular probes and the like. A preparation method of a porphyrin contrast agent modified by the diethylenetriamine pentaacetic acid gadolinium is concise and easy to operate.

Description

technical field The present invention relates to a porphyrin, in particular to a porphyrin modified with gadolinium diethylene triamine pentaacetate, its preparation method and use. Background technique Magnetic resonance imaging (MRI) technology has been widely used in the diagnosis of various diseases, especially for cardiovascular diseases and tumors. MRI contrast agent is a class of drugs that can enhance the contrast of magnetic resonance signals between normal tissue and diseased tissue, and display organ function and body fluid status. The paramagnetic metal complex Gd (diethylenetriaminepentaacetic acid) used as MRI contrast agent It has good biocompatibility with the human body and has been widely used clinically. It was later found that Gd-diethylenetriaminepentaacetic acid also has some shortcomings, such as too fast elimination and non-specific distribution in the body, so that the MRI image contrast cannot be significantly improved. Porphyrins can be selective...

AI Technical Summary

Problems solved by technology

However, neither the introduction of carboxyl group nor the introduction of sulfonic acid group improved the biocompatibility of porphyrin much.