Medicine composite for treating breast disease and preparation method thereof

Abstract

The invention relates to a medicine composite for treating a breast disease and a preparation method thereof. The medicine composite of the invention is prepared by the following raw materials in parts by weight: 6 to 14 salvia miltiorrhiza, 6-14 angelica, 4-12 zedoary, 6-14 radix bupleuri, 6-14 herba epimedii and 1-5 bloodsucker. The invention has the efficacies of promoting blood circulation and removing blood stasis, soothing liver, relieving upset, resolving hard lump, tonifying kidney and recuperating menstruation, is applicable to breast swell and pain, breast mass and breast hyperplasia before and during menstruation and has the advantages of good efficacy, small administration volume and convenient administration.

Description

technical field

[0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating breast diseases and a preparation method thereof. Background technique

[0002] Breast disease is a common and frequently-occurring disease in women, with an incidence rate as high as 80%. Hyperplasia of mammary glands is the most common breast disease, with an incidence of more than 60% of women of childbearing age, accounting for 75% of the total incidence of breast diseases, and a cancerous rate of 12.9-21.9%, which has become an important factor that seriously threatens women's health.

[0003] The pathogenic factors of breast disease are complex. Western medicine believes that the occurrence of this disease is mainly related to ovarian endocrine dysfunction, and there is no effective treatment method in clinic.

[0004] This disease belongs to the category of "breast addiction" in traditional Chinese m...

Examples

Embodiment 1

[0070] Embodiment 1 pharmaceutical composition capsule of the present invention

[0071] Danshen 1000g, Bupleurum 1000g, Angelica 1000g, Epimedium 1000g, Curcuma 800g, Leech 300g.

[0072] (1) get leeches, be ground into fine powder, and set aside;

[0073] (2) Take Salvia miltiorrhiza, Curcuma, Epimedium, reflux extraction with 8 times of 90% ethanol each time, 2 hours each time, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 (60°C) thick ointment, dried and pulverized to obtain a fine powder for subsequent use; dregs of the medicine were evaporated to ethanol for subsequent use;

[0074] (3) Take angelica and bupleurum, mix with the above-mentioned dregs, add 8 times the amount of water each time, decoct twice for 2 hours each time, filter the decoction; combine the filtrates and concentrate to a relative density of 1.30 (60°C ) thick paste, dried and pulverized to obtain fine powder for subseq...

Embodiment 2

[0076] Embodiment 2 pharmaceutical composition pill of the present invention

[0077] Danshen 700g, Bupleurum 700g, Angelica 1300g, Epimedium 1300g, Curcuma 1100g, Leech 200g.

[0078] (1) get leeches, be ground into fine powder, and set aside;

[0079] (2) Take Salvia miltiorrhiza, Zezhu, Epimedium, reflux extraction with 6 times of 85% ethanol each time for 3 times, each time for 1 hour, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 (60°C) thick ointment, dried and pulverized to obtain a fine powder for subsequent use; dregs of the medicine were evaporated to ethanol for subsequent use;

[0080] (3) Take angelica and bupleurum, mix with the above-mentioned dregs, add 10 times the amount of water to decoct 3 times, each time for 1 hour, filter the decoction, combine the filtrate and concentrate to a relative density of 1.30 (70°C) The thick paste is dried and pulverized to obtain a fine powder ...

Embodiment 3

[0082] Embodiment 3 pharmaceutical composition granule of the present invention

[0083] Danshen 1300g, Bupleurum 1300g, Angelica 700g, Epimedium 700g, Curcuma 700g, Leech 400g.

[0084] (1) get leeches, be ground into fine powder, and set aside;

[0085] (2) Take Salvia miltiorrhiza, Zezhu, Epimedium, reflux extract with 10 times the amount of 80% ethanol each time for 3 times, each time for 3 hours, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 (60°C) thick ointment, dried and pulverized to obtain a fine powder for subsequent use; dregs of the medicine were evaporated to ethanol for subsequent use;

[0086] (3) Take angelica and bupleurum, mix with the above dregs, add 12 times the amount of water to decoct 3 times, 2 hours each time, filter the decoction, combine the filtrate and concentrate to a relative density of 1.30 (60°C) The thick paste is dried and pulverized to obtain a fine powder f...

technical field

[0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating breast diseases and a preparation method thereof. Background technique

[0002] Breast disease is a common and frequently-occurring disease in women, with an incidence rate as high as 80%. Hyperplasia of mammary glands is the most common breast disease, with an incidence of more than 60% of women of childbearing age, accounting for 75% of the total incidence of breast diseases, and a cancerous rate of 12.9-21.9%, which has become an important factor that seriously threatens women's health.

[0003] The pathogenic factors of breast disease are complex. Western medicine believes that the occurrence of this disease is mainly related to ovarian endocrine dysfunction, and there is no effective treatment method in clinic.

[0004] This disease belongs to the category of "breast addiction" in traditional Chinese m...

Examples

Embodiment 1

[0070] Embodiment 1 pharmaceutical composition capsule of the present invention

[0071] Danshen 1000g, Bupleurum 1000g, Angelica 1000g, Epimedium 1000g, Curcuma 800g, Leech 300g.

[0072] (1) get leeches, be ground into fine powder, and set aside;

[0073] (2) Take Salvia miltiorrhiza, Curcuma, Epimedium, reflux extraction with 8 times of 90% ethanol each time, 2 hours each time, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 (60°C) thick ointment, dried and pulverized to obtain a fine powder for subsequent use; dregs of the medicine were evaporated to ethanol for subsequent use;

[0074] (3) Take angelica and bupleurum, mix with the above-mentioned dregs, add 8 times the amount of water each time, decoct twice for 2 hours each time, filter the decoction; combine the filtrates and concentrate to a relative density of 1.30 (60°C ) thick paste, dried and pulverized to obtain fine powder for subseq...

Embodiment 2

[0076] Embodiment 2 pharmaceutical composition pill of the present invention

[0077] Danshen 700g, Bupleurum 700g, Angelica 1300g, Epimedium 1300g, Curcuma 1100g, Leech 200g.

[0078] (1) get leeches, be ground into fine powder, and set aside;

[0079] (2) Take Salvia miltiorrhiza, Zezhu, Epimedium, reflux extraction with 6 times of 85% ethanol each time for 3 times, each time for 1 hour, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 (60°C) thick ointment, dried and pulverized to obtain a fine powder for subsequent use; dregs of the medicine were evaporated to ethanol for subsequent use;

[0080] (3) Take angelica and bupleurum, mix with the above-mentioned dregs, add 10 times the amount of water to decoct 3 times, each time for 1 hour, filter the decoction, combine the filtrate and concentrate to a relative density of 1.30 (70°C) The thick paste is dried and pulverized to obtain a fine powder ...

Embodiment 3

[0082] Embodiment 3 pharmaceutical composition granule of the present invention

[0083] Danshen 1300g, Bupleurum 1300g, Angelica 700g, Epimedium 700g, Curcuma 700g, Leech 400g.

[0084] (1) get leeches, be ground into fine powder, and set aside;

[0085] (2) Take Salvia miltiorrhiza, Zezhu, Epimedium, reflux extract with 10 times the amount of 80% ethanol each time for 3 times, each time for 3 hours, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate to a relative density of 1.30 (60°C) thick ointment, dried and pulverized to obtain a fine powder for subsequent use; dregs of the medicine were evaporated to ethanol for subsequent use;

[0086] (3) Take angelica and bupleurum, mix with the above dregs, add 12 times the amount of water to decoct 3 times, 2 hours each time, filter the decoction, combine the filtrate and concentrate to a relative density of 1.30 (60°C) The thick paste is dried and pulverized to obtain a fine powder f...

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