Vena cava shunt and portacaval transfer anticoagulation catheter and preparation method thereof

A vena cava and catheter technology, applied in the field of vena cava shunt and portacaval bypass anticoagulation catheter and its preparation, can solve the problems of lowering the tension of the tube wall, congestion of the middle and lower parts of the body, damage of internal organs, poor blood compatibility, etc., to achieve Effects of reducing wall tension, maintaining stability, and improving surgical safety

Active Publication Date: 2010-10-13
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the deficiencies in the above prior art, the object of the present invention is to provide a vena cava shunt and portacaval anticoagulant catheter and a preparation method thereof. The portocaval shunt catheter can simultaneously complete the intracavity shunt of the recipient's inferior vena cava and the non-invasive temporary portocavity shunt, avoiding the congestion of the middle and lower body and visceral damage during the anhepatic phase of liver transplantation, that is, the The application of the vena cava shunt catheter in the anhepatic stage can make more than half of the stagnant blood in the lower body and viscera flow back to the heart, and can maintain the stability of systemic hemodynamics. Insuffic

Method used

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  • Vena cava shunt and portacaval transfer anticoagulation catheter and preparation method thereof
  • Vena cava shunt and portacaval transfer anticoagulation catheter and preparation method thereof
  • Vena cava shunt and portacaval transfer anticoagulation catheter and preparation method thereof

Examples

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preparation example Construction

[0021] A preparation method of an anticoagulation catheter for vena cava shunt and portacaval bypass, the steps are as follows:

[0022] Step 1: Clean the surface of the medical polyvinyl chloride pipe with ethanol ultrasonically for 5 hours to 8 hours, then wash it with distilled water for 4 hours to 6 hours, and dry it naturally to obtain the medical polyvinyl chloride pipe with the cleaned surface;

[0023] Step 2: Take an aqueous solution with a mass ratio of 40% of polyethyleneimine and add glutaraldehyde and absolute ethanol with a mass ratio of 25% to prepare a 2.5wt% polyethyleneimine ethanol solution;

[0024] Step 3: Completely immerse the medical polyvinyl chloride pipe with the surface cleaned in 2.5wt% polyethyleneimine ethanol solution, soak it at 40°C-45°C for 4 hours to 6 hours, and dry it under vacuum at room temperature to obtain the surface bonded Polyethyleneimine medical polyvinyl chloride pipes;

[0025] Step 4: preparing a heparin aqueous solution with ...

Embodiment 1

[0030] Embodiment 1: A preparation method of an anticoagulation catheter for vena cava shunt and portacaval bypass, the steps are as follows:

[0031] Step 1: The surface of the medical polyvinyl chloride pipe is ultrasonically cleaned with ethanol for 5 hours, and then cleaned with distilled water for 4 hours, and the medical polyvinyl chloride pipe with the cleaned surface is obtained after natural air drying;

[0032] Step 2: Take an aqueous solution with a mass ratio of 40% of polyethyleneimine and add glutaraldehyde and absolute ethanol with a mass ratio of 25% to prepare a 2.5wt% polyethyleneimine ethanol solution;

[0033] Step 3: The medical polyvinyl chloride pipe with the surface cleaned is completely immersed in 2.5wt% polyethyleneimine ethanol solution, soaked at 40°C for 4 hours, and then dried under vacuum at room temperature to obtain the medical polyvinyl chloride pipe with the surface bound to polyethyleneimine. PVC piping;

[0034] Step 4: preparing a hepari...

Embodiment 2

[0038] Embodiment 2: A preparation method of anticoagulation catheter for vena cava shunt and portacaval bypass, the steps are as follows:

[0039] Step 1: Clean the surface of the medical polyvinyl chloride pipe with ethanol for 6 hours, then wash it with distilled water for 5 hours, and dry it naturally to obtain the medical polyvinyl chloride pipe with the cleaned surface;

[0040] Step 2: Take an aqueous solution with a mass ratio of 40% of polyethyleneimine and add glutaraldehyde and absolute ethanol with a mass ratio of 25% to prepare a 2.5wt% polyethyleneimine ethanol solution;

[0041] Step 3: The medical polyvinyl chloride pipe with the surface cleaned is completely immersed in a 2.5wt% polyethyleneimine ethanol solution, soaked at 41 ° C for 5 hours, and then dried under vacuum at room temperature to obtain a medical polyvinyl chloride pipe whose surface has been bound to polyethyleneimine. PVC piping;

[0042] Step 4: preparing a heparin aqueous solution with a mas...

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Abstract

The invention discloses a vena cava shunt and portacaval transfer anticoagulation catheter and a preparation method thereof. The catheter consists of a hooked bent tube type vena cava transfer catheter with a side hole and a portacaval shunt catheter; and intra-cavity transfer and non-invasive temporary portacaval shunt for receptor postcava can be finished at the same time through the hooked bent tube type vena cava transfer catheter with the side hole and the portacaval shunt catheter. Due to the adoption of polyethyleneimine-heparin combination technology, the preparation method for the catheter avoids stasis blood of the middle lower part and injury of internal organs at a liver-free stage during liver transplantation, realizes no haemorrhage during the liver transplantation, reduces the tube wall tension of the receptor postcava, ensures a broader operative field, is more convenient and safer, achieves simplification of the liver transplantation technology, has ideal anticoagulation effect, and avoids the defects of blood seepage during operation and poor blood compatibility.

Description

technical field [0001] The invention relates to a medical catheter and a preparation method thereof, in particular to an anticoagulation catheter for vena cava shunt and portacaval bypass and a preparation method thereof. Background technique [0002] Liver transplantation in the anhepatic period without the use of vena cava and portocaval shunt devices will bring a series of complications. Due to the blockage of the recipient's inferior vena cava, the amount of returning blood will drop by more than 50% and severe complications will occur. Hemodynamic disturbances lead to decreased blood perfusion in multiple organs. The recipient is also blocked by the blood return of the gastrointestinal viscera and lower limbs, resulting in severe congestion of viscera and lower limbs, and increased venous pressure, which makes it difficult to control intraoperative bleeding and oozing. Therefore, the role of portocaval bypass equipment is indispensable. . [0003] At present, roller p...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61L33/10A61F2/958
Inventor 吕毅季学闻马锋
Owner XI AN JIAOTONG UNIV
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