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Process for preparing bupleurum chinense injection

A technology for injection and Bupleurum, applied in the field of preparation of Bupleurum injection, can solve problems such as low content of Bupleurum volatile oil, poor product stability, toxic and side effects, and achieve the effects of avoiding toxic and side effects, improving stability and high bioavailability

Active Publication Date: 2011-10-26
SICHUAN DE PEI YUAN TRADITIONAL CHINESE MEDICINE SCI & TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The purpose of the present invention is to overcome the disadvantages of Bupleurum bupleuri injection in the prior art that the process is backward, the content of bupleurum volatile oil is low, the product stability is relatively poor, and the auxiliary material polysorbate 80 has certain toxic and side effects, and an improved bupleurum bupleuri is provided. Preparation method of injection

Method used

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  • Process for preparing bupleurum chinense injection
  • Process for preparing bupleurum chinense injection
  • Process for preparing bupleurum chinense injection

Examples

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Effect test

Embodiment 1

[0047] Bupleurum injection in the present embodiment is prepared by the following method:

[0048] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment:

[0049] Put the pulverized Bupleuri herb into the extraction kettle, and then pump the supercritical medical grade carbon dioxide fluid through the purifier, cooling system and high-pressure pump into the extraction kettle at a flow rate of about 20kg / h. Extraction under the condition of 20MPa pressure for 1.5h;

[0050] Carry out two-stage separation to the extract, the operating conditions of the separation tank I are: pressure 12 MPa, temperature 40 °C, the operating conditions of the separation tank II are: pressure 6 MPa, temperature 25 °C; from the outlet of the two-stage separation tank Collect supercritical product of Radix Bupleuri;

[0051] (2) Distill the Bupleurum supercritical product extracted in...

Embodiment 2

[0055] The preparation method of the Bupleurum injection of the present embodiment is as follows:

[0056] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment: the extraction process is the same as in Example 1, wherein the flow rate of the supercritical medical grade carbon dioxide fluid is 25kg / h, The extraction conditions are: 45°C, 25MPa, the extraction time is 1h, the operating conditions of the separation tank I are: the pressure is 12 MPa, the temperature is 35°C, the operating conditions of the separation tank II are: the pressure is 6 MPa, the temperature is 30°C; The supercritical product with Bupleurum volatile oil as the main component is collected from the outlet of the two-stage separation kettle;

[0057] (2) The Bupleurum supercritical product extracted in step (1) was distilled with 80 times the amount of water for 3 h to obtain about 2000 mL of...

Embodiment 3

[0061] The preparation method of the Bupleurum injection of the present embodiment is as follows:

[0062] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment: the extraction process is the same as in Example 1, wherein the flow rate of the supercritical medical grade carbon dioxide fluid is 25kg / h, The extraction conditions are: 35°C, 20MPa, the extraction time is 2h, the operating conditions of the separation tank I are: the pressure is 8 MPa, the temperature is 35°C, the operating conditions of the separation tank II are: the pressure is 7 MPa, the temperature is 30°C; Collected from the outlet of the two-stage separation kettle to obtain the supercritical product of Bupleuri ；

[0063] (2) The Bupleurum supercritical product extracted in step (1) was distilled with 60 times the amount of water for 2 h to obtain about 1500 mL of distillate.

[0064] (3) Add...

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Abstract

The present invention discloses a method for preparing a bupleurum chinense injection. A process for preparing the bupleurum chinense injection comprises the following steps of: extracting a supercritical product taking a bupleurum chinense volatile oil as a main component by using a CO<2> supercritical extraction technique; purifying the supercritical product by a distillation method; and after adding an HP-Beta-CD into the obtained distillate for cladding, adding a corresponding pharmaceutical adjuvant to prepare the bupleurum chinense injection. The process for preparing the bupleurum chinense injection provided by the invention can correctly perform qualitative and quantitative analysis on the volatile oil which is contained in a medicament, and meanwhile, can increase the yield of the bupleurum chinense volatile oil, improve the dissolubility of the bupleurum chinense volatile oil, increase the stability of the medicament, promote medicament absorption and improve bioavailability on the basis of not changing pharmaceutical materials.

Description

technical field [0001] The invention relates to a preparation process of Bupleurum injection. Background technique [0002] Bupleurum is a large number of commonly used traditional Chinese medicines. It is listed as the top grade in "Shen Nong’s Materia Medica". It is the dried root of Bupleurum chinense DC or Bupleurum scorzonerifolium Willd. It is an important medicine for reconciling exterior and interior, soothing the liver, and promoting yang. In traditional Chinese medicine, it is mainly used for the treatment of colds and fever, alternating cold and heat, chest and hypochondrium pain, irregular menstruation, uterine prolapse, anal prolapse and other diseases. Modern chemical research has found that the main chemical components of Bupleuri are volatile oil, saikosaponins (saikosapoins a, b, c, d), polysaccharides, and flavonoids, among which the main components of volatile oil are small molecule alkenes, terpenes, and phenols. eugenol, caproic acid, gamma-undecanoic l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/233A61K9/14A61K9/19A61K9/08A61P11/00A61P31/00A61P31/16A61P33/06
Inventor 马家骅索志荣马璇杨兴旺
Owner SICHUAN DE PEI YUAN TRADITIONAL CHINESE MEDICINE SCI & TECH DEV CO LTD
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