Application of gentiamarin in preparing medicine for preventing and treating acute pancreatitis

Abstract

The invention belongs to the field of traditional Chinese medicine preparation, relating to application of monomer gentiamarin extracted in the traditional Chinese medicine in preparing medicine for preventing and treating acute pancreatitis. In the invention, a model which is recognized by academic circles at home and abroad and is formed by continuously injecting caerulein to cause the acute pancreatitis of mice in enterocoelia and carrying out bezoar sodium taurocholate retrograde injection in cholangiopan so as to cause the acute pancreatitis of a rat, is adopted to study the action of the gentiamarin. The experiment result discloses that the gentiamarin has obvious function of resisting the acute pancreatitis caused by various reasons, and the action mechanism for resisting the acute pancreatitis is related to the releasing of the inflammatory factor, reduction of concentration of the tumor necrosis factor-alpha and interleukin-1beta in the serum or tissue, the increasing of the glutathione peroxidase activity in the serum or tissue, and the clearing of the radical and the expression of NF-kB P65.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy and relates to a new medical application of gentiopicroside. Background technique [0002] Pancreatitis refers to the inflammatory disease of pancreatic tissue, which can be divided into acute pancreatitis and chronic pancreatitis according to the speed of pathological changes. Clinically, about 80% of patients have clear etiology. Due to the special anatomical structure of the pancreas and adjacent organs, various pathophysiological changes of the liver, biliary tract and pancreas are closely related to the pathogenesis of pancreatitis. Biliary tract disease, heavy drinking and overeating, surgical trauma and drugs can induce pancreatitis. The incidence of acute pancreatitis is high, about 30 / 100,000, especially severe acute pancreatitis, accounting for about 15% of patients with acute pancreatitis, and the mortality rate is as high as 12%-15% (Schmidt J, Rattner DW, Lewandr...

AI Technical Summary

Problems solved by technology

[0004] Gentiopicroside is a monoterpene compound, which belongs to the structure of split ring iridoid glycosides. It is a common ingredient in a variety of Gentianaceae plants, and it is also one of the main active ingredients of the traditional Chinese medicine Gentiana. The role has not been reported

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