Method for determining content of polyhexamethylene guanidine hydrochloride

Abstract

The invention provides a method for determining the content of polyhexamethylene guanidine hydrochloride, which is suitable for content determination of the raw material of the polyhexamethylene guanidine hydrochloride and the polyhexamethylene guanidine hydrochloride in the related disinfectant products. The invention adopts a colloid charge titration principle and a volumetric analysis method, wherein the principle is that polycation reacts with polyanion, polyvinylsulfate (PVSK) is polyanion titrant, and the polyhexamethylene guanidine hydrochloride is cationic polyelectrolyte; and the method is that the PVSK and the polyhexamethylene guanidine hydrochloride are quantified to perform reaction, after reaching equivalence point, the PVSK with surplus trace combines with toluidine blue, thus the solution turns from blue to amaranth, which indicates the end. The invention can replace the traditional standard curve method to determine the content of the polyhexamethylene guanidine hydrochloride. Under the acid environment, the PVSK and the polyhexamethylene guanidine hydrochloride are quantified to perform reaction, the end color changes obviously and the result is exact. Compared with the standard curve method, the method of the invention has the advantages of convenience, rapidness and easy operation.

Description

technical field [0001] The invention relates to a method for determining the content of polyhexamethyleneguanidine hydrochloride, which is applied to the content determination of polyhexamethyleneguanidine hydrochloride raw materials and the content determination of polyhexamethyleneguanidine hydrochloride in related disinfectant products. Background technique [0002] Polyhexamethyleneguanidine hydrochloride is easily soluble in water, its aqueous solution is colorless and odorless, non-flammable and non-explosive, it has a strong ability to kill bacteria and viruses, and it has a broad spectrum and high efficiency, and has long-term antibacterial effect. It has no corrosion effect on various metal materials, is degradable, has no pollution to the environment, has low toxicity, and is safe to use, so it is widely used in beverage and food processing industries, for disinfection of drinking water and swimming pools, lake water, ponds, cooling towers, Algae removal for founta...

AI Technical Summary

Problems solved by technology

[0005] The most commonly used method for determining the content of polyhexamethyleneguanidine hydrochloride is the standard curve method, which adopts polyhexamethyleneguanidine hydrochloride standard substance to be configured into standard solutions (at least 8 concentrations), and adopts tetrabromofluorescein solution as indicator Solution and glycine buffer solution, draw a standard curve, prepare the concentration of the sample to be tested in the range of 0.2 to 10 mg / L, and calculate the content of the active ingredient according to the absorbance of the standard solution and the sample sample. This method is cumbersome and complicated to operate. time consuming

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