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Tripterygium wilfordii hook extract cataplasm and preparation method thereof

A technology of Tripterygium wilfordii and its extract, which is applied in the field of tripterygium wilfordii extract cataplasm and its preparation, can solve problems such as toxic side effects, death, acute renal failure, etc., achieve enhanced anti-inflammatory effects, increase drug concentration, and increase drug concentration. effect of concentration

Active Publication Date: 2011-04-13
苏州迪星生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is very toxic. Currently, the oral preparation of Tripterygium wilfordii extract is used, and the clinical reaction has more toxic and side effects after taking it. In severe cases, acute renal failure or even death may occur.

Method used

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  • Tripterygium wilfordii hook extract cataplasm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare Tripterygium wilfordii extract as follows:

[0031] Weigh a sufficient amount of Tripterygium wilfordii, coarsely crush it, heat and reflux with 55% ethanol to extract three times, filter, combine the filtrate, recover the ethanol from the filtrate and concentrate it into an extract extract with a relative density of 1.35.

[0032] Prepare the cataplasm matrix as follows:

[0033] 1. Add 1 part of lactic acid to 15 parts of water, and mix well. Then add 4 parts of chitosan, heat to 40-65°C and stir to dissolve completely, and mix evenly, as phase A.

[0034] 2. Add 6 parts of polyvinyl alcohol to 10 parts of water, heat to 55-80°C to dissolve, stir evenly, and use it as phase B.

[0035] 3. Add 8 parts of Mingjiao to 12 parts of water, heat to 40-60°C and stir to dissolve completely, and mix well to form C phase.

[0036] 4. Add 4 parts of polyvinylpyrrolidone and 8 parts of carrageenan to 12 parts of water, heat to 40-60°C and stir to dissolve completely, an...

Embodiment 2

[0040] Prepare Tripterygium wilfordii extract as follows:

[0041] Weigh a sufficient amount of Tripterygium wilfordii, coarsely crush it, heat and reflux with 55% ethanol to extract three times, filter, combine the filtrate, recover the ethanol from the filtrate and concentrate it into an extract extract with a relative density of 1.35.

[0042] Prepare the cataplasm matrix as follows:

[0043] 1. Add 0.1 part of lactic acid to 10 parts of water, and mix well. Then add 0.5 parts of chitosan, heat to 40-65°C and stir to dissolve completely, and mix evenly, as Phase A.

[0044] 2. Add 12 parts of polyvinyl alcohol to 16 parts of water, heat to 55-80°C to dissolve, stir evenly, and use it as phase B.

[0045] 3. Add 1 part of gelatin to 8 parts of water, heat to 40-60°C and stir to dissolve completely, and mix evenly, as phase C.

[0046] 4. Add 8 parts of polyvinylpyrrolidone and 2 parts of carrageenan to 22 parts of water, heat to 40-60°C and stir to dissolve completely, an...

Embodiment 3

[0050] Prepare Tripterygium wilfordii extract as follows:

[0051] Take a sufficient amount of Tripterygium wilfordii, coarsely crush it, heat and reflux with 30% ethanol to extract three times, filter, combine the filtrate, recover the ethanol from the filtrate and concentrate it into an extract with a relative density of 1.40.

[0052] Prepare the cataplasm matrix as follows:

[0053] 1. Add 3 parts of lactic acid to 20 parts of water, and mix well. Then add 10 parts of chitosan, heat to 40-65°C and stir to dissolve completely, and mix evenly, as Phase A.

[0054]2. Add 1 part of polyvinyl alcohol to 8 parts of water, heat to 55-80°C to dissolve, stir evenly, and use it as phase B.

[0055] 3. Add 12 parts of gelatin to 16 parts of water, heat to 40-60°C and stir to dissolve completely, and mix evenly to form phase C.

[0056] 4. Add 0.5 parts of polyvinylpyrrolidone and 14 parts of carrageenan to 10 parts of water, heat to 40-60°C and stir to dissolve completely, and mix...

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Abstract

The invention discloses a tripterygium wilfordii hook extract cataplasm and a preparation method thereof. The tripterygium wilfordii hook extract cataplasm provided by the invention contains tripterygium wilfordii hook extract and a substrate, wherein the weight ratio of the tripterygium wilfordii hook extract to the substrate is 1:3-12. The tripterygium wilfordii hook extract cataplasm provided by the invention improves the clinical medication security of the tripterygium wilfordii hook, increases the medicament concentration of the tripterygium wilfordii hook at inflammatory joints, reduces adverse reaction and toxic or side effect caused by medicaments, and has enhanced anti-inflammatory action and reduced blood concentration fluctuation.

Description

technical field [0001] The present invention relates to a kind of anti-inflammation and immunomedicine transdermal dosage form for prevention and treatment of rheumatoid arthritis, erythema multiforme, psoriasis, etc., specifically tripterygium wilfordii extract cataplasm and its preparation method . Background technique [0002] Tripterygium wilfordii is the root of Euonymus plant Tripterygium wilfordii, mainly produced in Fujian, Zhejiang, Anhui, Henan and other places. It has the functions of expelling wind and dampness, dredging collaterals and relieving pain, reducing swelling and relieving pain, detoxifying and killing insects. It is used for damp-heat nodules and cancerous tumors to accumulate poison. It is used clinically to treat leprosy reactions, rheumatoid arthritis, etc. Pharmacological studies have also shown that it has anti-tumor and anti-inflammatory effects. However, it is highly toxic. Currently, the oral preparation of Tripterygium wilfordii extract is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K9/70A61K47/42A61P17/06A61P19/02A61P19/04A61P29/00
Inventor 钱建吴治军施亭
Owner 苏州迪星生物医药科技有限公司
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