Quinapril-contained compound preparation for treating hypertension

A compound preparation, the technology of quinapril, applied in the field of medicine, can solve the problems of low blood pressure control rate, poor patient compliance, and non-optimized ratio, and achieve high blood pressure rate, quick effect, and reduce adverse reactions. Effect

Active Publication Date: 2011-04-13
杨硕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.
In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0010] Embodiment 1-4 list is as follows:

[0011] In the embodiment, the conventional method in the pharmaceutical industry is used, and the formula shown in the table below is prepared into tablets, and the pharmaceutically acceptable carrier-adjuvant used for making the tablet is a conventional adjuvant in the art. Wherein the proportioning of its main components is as follows:

[0012]

[0013] Simultaneously, use conventional method in the pharmaceutical industry in the embodiment, can also be prepared into capsule, soft capsule, granule, powder, sustained and controlled release agent or injection dosage form, pharmaceutically acceptable carrier--all adjuvants used are the original formulations of this dosage form Common excipients in the field.

Embodiment 5

[0014] Embodiment 5: The curative effect test of the compound preparation of the present invention for treating hypertension:

[0015] The following will illustrate the therapeutic effect of the pharmaceutical composition of the present invention on hypertension through human pharmacodynamic experiments.

[0016] 1. General information:

[0017] Among the 500 clinical hypertensive patients, 190 were 40-50 years old; 190 were 51-60 years old, and 120 were 61-70 years old.

[0018] 2. Diagnostic criteria: According to the "Guidelines for the Prevention and Treatment of Hypertension in China", hypertension is defined as: systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg without taking antihypertensive drugs.

[0019] 3. Therapeutic method: 500 hypertensive patients are randomly divided into 5 groups, and each group adopts the compound preparation medicine obtained in Examples 1-5 of the present invention respectively to make tablets and take it orally on...

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PUM

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Abstract

The invention relates to a quinapril-contained compound preparation for treating hypertension, comprising the following components: levamlodipine or levamlodipine pharmaceutically-acceptable salt, hydrochlorothiazide, quinapril or pharmaceutically-acceptable salt thereof as main components and a pharmaceutically-acceptable carrier as an auxiliary material, wherein in per preparation unit of the levamlodipine., the levamlodipine or the levamlodipine pharmaceutically-acceptable salt is 2.5-10.0mg. The compound preparation fully performs the action mechanism of drug complementation according to drug combination to enhance the curative effect, rapidly make the blood pressure standard-reaching rate reach 82 percent, reduce the adverse reaction related with the increase of a certain dose and keep the longer acting time. The compound preparation takes effect rapidly, has high blood pressure standard-reaching rate, small side effect and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation containing quinapril for treating hypertension, which belongs to the field of medicines. Background technique: [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin Ⅱ receptor blockers (ARBs), etc., but it is difficult to achieve the target for a single drug treatment of hypertension in the short term , most...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K38/05A61P9/12A61K31/4422A61K31/549
Inventor邬林祥邬林云
Owner杨硕