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Lisinopril-containing compound preparation for treating hypertension

A compound preparation and high blood pressure technology, applied in the field of medicine, can solve the problems of non-optimized ratio, low blood pressure control rate, poor patient compliance, etc., and achieve the effect of reducing adverse reactions, high blood pressure rate, and quick effect

Active Publication Date: 2011-04-13
YUANHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.
In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0010] Embodiment 1-4 list is as follows:

[0011] In the embodiment, the conventional method in the pharmaceutical industry is used, and the formula shown in the table below is prepared into tablets, and the pharmaceutically acceptable carrier-adjuvant used for making the tablet is a conventional adjuvant in the art. Wherein the proportioning of its main components is as follows:

[0012]

[0013] Simultaneously, use conventional method in the pharmaceutical industry in the embodiment, can also be prepared into capsule, soft capsule, granule, powder, sustained and controlled release agent or injection dosage form, pharmaceutically acceptable carrier--all adjuvants used are the original formulations of this dosage form Common excipients in the field.

Embodiment 5

[0014] Embodiment 5: The curative effect test of the compound preparation of the present invention for treating hypertension:

[0015] The following will illustrate the therapeutic effect of the pharmaceutical composition of the present invention on hypertension through human pharmacodynamic experiments.

[0016] 1. General information:

[0017] Among the 400 clinical cases of hypertensive patients, 150 cases were 40-50 years old; 150 cases were 51-60 years old, and 100 cases were 61-70 years old.

[0018] 2. Diagnostic criteria: According to the "Guidelines for the Prevention and Treatment of Hypertension in China", hypertension is defined as: systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg without taking antihypertensive drugs.

[0019] 3. Therapeutic method: 400 hypertensive patients are randomly divided into 4 groups, and each group adopts the compound preparation medicine obtained in Examples 1-4 of the present invention respectively to make ta...

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PUM

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Abstract

The invention relates to a lisinopril-containing compound preparation for treating hypertension, which comprises the main components of L-amlodipine or pharmaceutically acceptable salt thereof, hydrochlorothiazide and lisinopril or pharmaceutically acceptable salt thereof, and the auxiliary component of a pharmaceutically acceptable carrier, wherein the content of the L-amlodipine or the pharmaceutically acceptable salt thereof in unit preparation is 2.5-10.0mg. The invention has the advantages of fully exerting medicine compensation action mechanism through medicine combination therapy, increasing curative effect, quickly reaching the standards, making the compliance rate of blood pressure reach 82%, reducing adverse effect associated with the dose increase of certain medicine and keeping longer action time. The compound preparation has the characteristics of quick effect taking, high compliance rate of blood pressure, little side effect and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation containing lisinopril for treating hypertension, which belongs to the field of medicines. Background technique: [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin Ⅱ receptor blockers (ARBs), etc., but it is difficult to achieve the target for a single drug treatment of hypertension in the short term , mos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61P9/12A61K31/4422A61K31/549
Inventor 邬林祥邬林云
Owner YUANHE PHARMA CO LTD
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