Mesenchymal stem cell particles

A technology of stem cells and particles, used in the fields of development, cell biology, molecular biology and genetics, to solve problems such as unmet needs
CN102014934AInactive Publication Date: 2011-04-13AGENCY FOR SCI TECH & RES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AGENCY FOR SCI TECH & RES
Publication Date
2011-04-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

We describe a particle secreted by a mesenchymal stem cell and comprising at least one biological property of a mesenchymal stem cell. The biological property may comprise a biological activity of a mesenchymal stem cell conditioned medium (MSC- CM) such as cardioprotection or reduction of infarct size. The particle may comprise a vesicle or an exosome.
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Description

Invention field

[0001] The invention relates to the fields of development, cell biology, molecular biology and genetics. More specifically, the present invention relates to a method for deriving mesenchymal stem cells from embryonic stem cells. Background of the invention

[0002] Different from differentiated cells, stem cells have the ability to divide and self-renew or differentiate into phenotypically and functionally different daughter cells (Keller, Genes Dev. 2005; 19:1129-1155; Wobus and Boheler, Physiol Rev. 2005 ; 85: 635-678; Wiles, Methods in Enzymology. 1993; 225: 900-918; Choi et al., Methods Mol Med. 2005; 105: 359-368).

[0003] Mesenchymal stem cells (MSC) are pluripotent stem cells, which have written evidence of therapeutic efficacy in treating musculoskeletal injuries, improving heart function in cardiovascular diseases, and improving the severity of GVHD (Le Blanc and Pittenger, 2005). Due to lineage limitations, they have a limited but strong potential to di...

Claims

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