Valve aortal stent planted above opening of percutaneous coronary

A technology for aorta and valves, applied in the direction of stents, heart valves, etc., can solve the problems of impact, sudden death of patients, and impact on coronary artery openings, etc., and achieve the effect of easy affixation, simple operation, and convenient sewing

Active Publication Date: 2014-08-20
中国人民解放军第101医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The risk of percutaneous aortic valve replacement mainly comes from the possibility that the placement of the aortic valve stent may affect the coronary artery ostium. Once the coronary artery ostium is involved, it may lead to sudden death of the patient
Therefore, imagine whether aortic stents with valves can be implanted above the coronary artery ostium to avoid the coronary artery ostium, which can significantly reduce the mortality rate in theory, but may have a certain impact on coronary blood flow. What is the real situation? There are no related reports

Method used

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  • Valve aortal stent planted above opening of percutaneous coronary
  • Valve aortal stent planted above opening of percutaneous coronary
  • Valve aortal stent planted above opening of percutaneous coronary

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] like figure 1 and 2 Shown: a valved aortic stent for implantation above the percutaneous coronary ostium, the stent is composed of a tubular stent 1 and an artificial valve 2, the tubular stent 1 is a mesh tubular structure, the tubular structure The mesh is diamond-shaped, and the valve 2 is composed of a wavy valve ring 3 and leaflets 4. The wavy valve ring 3 is folded and bent into three equal-length half-moon arc structures by alloy wires, and the joints are made of nickel Titanium alloy kneading fixed, such as image 3 The valve leaflet 4 is made into a flexible valve from the decellularized animal pericardium. The valve leaflet 4 is attached and its edge is sutured on the arc-shaped metal wire of the wavy valve ring 3 with thread, and the other side is free to form three semilunar sinuses, namely The valve is made; the wave-shaped valve ring 3 is placed on the waist of the tubular stent 1, and the arcs protrude toward the disk surface of the right ventricle.

...

Embodiment 2

[0018] Following is the application of the present invention in experiment:

[0019] 1) Preparation of experimental animals:

[0020] 20 healthy and clean experimental dogs, 12 females and 8 males, weighing (17.7±3.1) kg. Preoperative ECG chest X-ray and cardiac color Doppler ultrasound were normal, and no heart murmur was heard on auscultation. Water and food were fasted for 8 hours after surgery. Ketamine (10mg.kg-1) was injected intramuscularly for induction of anesthesia, and 2.5% pentobarbital sodium was injected intravenously in 10ml. After the anesthesia was satisfactory, the precordial area, the inner side of the limbs and the body hair near the trunk were shaved. All experimental animals were treated in accordance with The "Regulations on the Administration of Experimental Animals" promulgated by the National Science and Technology Commission in 1988.

[0021] 2) Establishment and grouping of canine acute aortic valve rupture model:

[0022] Routinely disinfect th...

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PUM

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Abstract

The invention relates to a valve aortal stent planted above an opening of percutaneous coronary. The stent provided by the invention is composed of a tubular stent and an artificial valve, wherein, the tubular stent is of a net-shaped tubular structure; the mesh of the tubular structure is in a diamond shape; the valve is composed of a wavy valve ring and a valve leaflet; the wavy valve ring is bent into three half-moon arc-shaped structures with equal length by alloy wires; and the valve leaflet is wrapped into a flexible valve by an animal heart. The valve stent provided by the invention is woven by hyperelastic nickel-titanium alloy wires, and has better compliance; the valve is convenient to tailor, is connected with the stent through the valve ring, and is exactly fixed; and the valve ring has small possibility of displacing, is convenient in operation and is safe.

Description

technical field [0001] The invention belongs to the field of aortic artificial stent with a valve, in particular to an aortic stent with a valve for implantation above a percutaneous coronary ostium. Background technique [0002] Explosive weapons are widely used in modern warfare. Explosive weapons mainly cause injuries through high-energy fragments and shock waves generated at the moment of explosion. The incidence of chest blast injury caused by shock wave is significantly increased, and the mortality rate of chest blast injury is high. It has been reported in the literature that the incidence of acute heart valve rupture caused by chest blast injury reaches 9% [1-3]. Among them, the incidence of aortic valve injury is the highest, mainly manifested as acute aortic insufficiency, and severe cases may quickly endanger life. Conventional treatment measures must be replaced by emergency surgical thoracotomy and artificial aortic valve, but very few wounded can really recei...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/90A61F2/24
Inventor 宗刚军陈景开吴刚勇叶光明夏阳陈满清
Owner 中国人民解放军第101医院
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