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Method for enriching and purifying veratric acid in globeflower

A technology of veratruic acid and nasturtium, which is applied in the field of purification of veratrol and veratrol in nasturtium by using macroporous adsorption resin to enrich and purify nasturtium, can solve the problems of low extraction rate and low extraction purity, and achieve extraction purity. High, fast adsorption, large surface area

Active Publication Date: 2013-11-06
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying veratrol in nasturtium by using macroporous adsorption resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a kind of method that utilizes macroporous adsorption resin to enrich and purify veratrol in nasturtium, its steps are as follows:

[0027] (1) Pass through a 60-mesh sieve after the dried nasturtium flower is crushed, and reflux extract with 60% ethanol with 5 times the volume of the nasturtium flower powder for 4 hours;

[0028] (2) Suction filtration of the nasturtium extract treated in step (1) to obtain the extract and reclaim the primary extract of the solvent under reduced pressure;

[0029] (3) Heat and dissolve the obtained primary extract with ethanol, add purified water with a volume 5 times the volume of the extract alcohol solution for extraction, then use acid to adjust its pH value to 2.0, let stand, suction filter, and recover the solvent under reduced pressure Obtain veratrol crude extract;

[0030] (4) the obtained veratrol acid extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is...

Embodiment example 2

[0035] Implementation case 2: A method for enriching and purifying veratrol in nasturtium using macroporous adsorption resin, the steps are as follows:

[0036] (1) After crushing the dried nasturtium, pass through a 10-mesh sieve, soak for 2 hours with 80% ethanol which is 8 times the volume of the nasturtium powder, and then reflux and extract for 6 hours;

[0037] (2) Suction filtration of the nasturtium extract treated in step (1) to obtain the extract and reclaim the primary extract of the solvent under reduced pressure;

[0038] (3) heating and dissolving the obtained initial extract with ethanol, adding purified water whose volume is 8 times the volume of the extract alcohol solution for extraction, then adjusting its pH value to 2.3 with acid, standing, suction filtration, and recovering the solvent under reduced pressure Obtain veratrol crude extract;

[0039] (4) the obtained veratronic acid crude extract is adsorbed with a macroporous adsorption resin, and the macr...

Embodiment example 3

[0044] Implementation case 3: a method for enriching and purifying veratrol in nasturtium using macroporous adsorption resin, the steps are as follows:

[0045] (1) Pass through an 80-mesh sieve after the dried nasturtium is pulverized, and extract with 75% ethanol with 10 times the volume of the nasturtium powder for 6 hours;

[0046] (2) Suction filtration of the nasturtium extract treated in step (1) to obtain the extract and reclaim the primary extract of the solvent under reduced pressure;

[0047] (3) The obtained primary extract is heated and dissolved with ethanol, and the purified water whose volume is 10 times the volume of the extract alcohol solution is added to extract, then the pH value is adjusted to 2.5 with acid, and the solvent is recovered after standing, suction filtration, and decompression Obtain veratrol crude extract;

[0048] (4) the obtained veratronic acid crude extract is adsorbed on a macroporous adsorption resin chromatography column, and the mac...

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PUM

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Abstract

The invention belongs to the field of natural organic chemistry, and particularly relates to a method for enriching and purifying veratric acid in globeflower by using macroporous adsorbent resin. By using macroporous adsorption technology to separate and purify veratric acid, the invention has the characteristics of good adsorption selectivity for veratric acid, high adsorption and desorption speed, high adsorption capacity, abundant material sources, low production cost, obvious separation effect and high extraction purity, can be used for extracting veratric acid conveniently and quickly, can be used to obtain a semi-finished product of which the content of veratric acid is higher than 30% and a final product of which the content of veratric acid is higher than 90%, and can overcome the defects of low extraction yield and low extraction purity in the conventional method. The macroporous adsorbent resin, which has the advantages of stable physicochemical properties, large surface area, high exchange speed, high mechanical strength, high antipollution capability and high thermal stability, is used for selectively adsorbing veratric acid from the solution in a physical adsorption mode; and the invention has the advantages of high adsorption and desorption speed, and high adsorption capacity.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry, and relates to a method for purifying veratrol, in particular to a method for enriching and purifying veratrol in nasturtium by using a macroporous adsorption resin. Background technique: [0002] Trollius (scientific name: Trollius chinensis Bunge) is a plant of the genus Trollius in the family Ranunculaceae. Annual or perennial herbs. Plant height 30-100 cm. Stems soft and clinging. The leaves are round like lotus leaves, the flower shape is similar to trumpets, and the calyx tube is slender, often yellow, orange, and red. There is a variety of dwarf nasturtium, which has a compact and low plant shape, dense branches and leaves, and a plant height of only 30 cm. It is very suitable for potted plants and ornamental. The flowering period is from February to May. Flowers contain veratric acid, orientin, vitexin, veratramide, and palmitic acid. It has medicinal functions, can clear aw...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C65/21C07C51/42C07C51/47
Inventor 姚德坤姚德利闫峰黄运生刘德文姚航郑君
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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