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Pharmaceutical composition and health food composition containing youngia denticulata extract, fraction thereof, or compound isolated therefrom as active ingredient for improving liver function

A technology of active ingredients and compositions, which can be applied to medical preparations containing active ingredients, pharmaceutical combinations, organic active ingredients, etc., can solve the problems of non-disclosure, etc., and achieve the effect of non-cytotoxicity

Inactive Publication Date: 2011-09-14
KOREA INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, the cancer preventive use or hepatoprotective effect of the extract, its fraction, or the compound isolated therefrom has not been known at all in the past, and in addition, there is absolutely no information about the specific route through which such activity is obtained. was made public

Method used

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  • Pharmaceutical composition and health food composition containing youngia denticulata extract, fraction thereof, or compound isolated therefrom as active ingredient for improving liver function
  • Pharmaceutical composition and health food composition containing youngia denticulata extract, fraction thereof, or compound isolated therefrom as active ingredient for improving liver function
  • Pharmaceutical composition and health food composition containing youngia denticulata extract, fraction thereof, or compound isolated therefrom as active ingredient for improving liver function

Examples

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Embodiment approach

[0052] The present invention provides a pharmaceutical composition for preventing cancer comprising an extract of quail extract as an active ingredient.

[0053] Hereinafter, the present invention will be described in detail.

[0054] According to the present invention, the extract of the slit quail can be obtained from the slit or its dried product, and the slit can be collected, cultivated or marketed for unlimited use.

[0055] According to the method of extraction devices such as supercritical extraction, subcritical extraction, high-temperature extraction, high-pressure extraction or ultrasonic extraction, or the method of utilizing adsorption resins including XAD and HP-20, the extract of dentate yellow quail according to the present invention can be used. and other conventional extraction methods in the field, and preferably can be prepared by heating, and reflux extraction or extraction at room temperature, but not limited thereto. The number of times of extraction is...

preparation example 1

[0108] [Preparation Example 1: Preparation of Cracked Yellow Quail Extract]

[0109] The yellow quail collected in Pyeongchang, Gangwon-do, was dried in the shade and finely cut to an appropriate size, and 1 kg of yellow quail and 5 L of 94% ethanol were added to the extraction container and extracted by ultrasonic waves. On the other hand, the extract was obtained by filtering with filter paper. The extraction process was repeated 3 times, and then the solvent was concentrated and dried under reduced pressure to obtain 70 g of ethanol extract.

preparation example 2

[0110] [Preparation Example 2: Preparation of Cracked Yellow Quail Fraction]

[0111] The ethanol extract was systematically fractionated and fractionated sequentially with n-hexane, ethyl acetate, n-butanol and each yielded 18.7 g in n-hexane and 2.3 g in ethyl acetate, Fractions of 5.8 g in n-butanol and 34.4 g in water were harvested.

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Abstract

The present invention relates to a pharmaceutical composition for preventing cancer or improving liver function, containing Youngia denticulata extract, a fraction thereof, or one or more compounds as an active ingredient selected from a group consisting of chlorogenic acid, 3,5-di-O-caffeoylquinic acid, Youngiaside A, Youngiaside B, and Youngiaside C which are isolated therefrom. The Youngia denticulata extract, a fraction thereof, or a compound isolated therefrom according to the present invention enhances activation of detoxifying enzymes in the liver, including quinone reductase(QR) of a marker enzyme for preventing cancer and an antioxidant response element(ARE) of an antioxidant responsive factor. The extract, fraction, or compound is not cytotoxic as well protects the liver from liver injury induced by ethanol or acetaminophen.; Therefore, the composition according to the present invention can be useful in medicinal products and health foods for preventing cancer or improving liver function.

Description

【Technical field】 [0001] The present invention relates to a composition for preventing cancer or improving liver function, which contains extract of Youngia denticulata (Youngia denticulata), its fraction, or a compound isolated therefrom as an active ingredient, and in more detail, relates to an enzyme exhibiting excellent detoxification Active, non-cytotoxic extract containing dentate yellow quail, its fraction or selected from chlorogenic acid, 3,5-di-O-caffeoylquinic acid, yellow quailin A, yellow quail A pharmaceutical composition for cancer prevention or improvement of liver function, and a health functional food composition in which one or more compounds of glucoside B and yellow quail glycoside C are used as active ingredients. 【Background technique】 [0002] Today, when research on cancer has been carried out intensively for more than 30 years, the incidence of cancer continues to increase due to environmental pollution, wrong eating habits, etc., and the incidence ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P35/00A61K31/222A61K31/7028
CPCA61K36/28A61K31/222A61K31/7028A61P1/16A61P35/00A61K31/704A61K31/7042
Inventor 卢周嫄S·B·李尹智浩郑相勋李熙珠姜京秀柳智慧金明洙安手镛金宗焕
Owner KOREA INST OF SCI & TECH
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