Compound combination medicament for treating COPD, preparation method and application thereof

A COPD and drug technology, applied in the field of compound combination drugs, can solve the problems of non-promoting application, prescription correspondence and poor effect, and achieve the effect of thorough curative effect, easy operation and short course of treatment

Inactive Publication Date: 2011-09-21
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently defects in TCM syndrome differentiation. Phlegm-heat and phlegm-dampness are not the majority of patients in the acute exacerbation stag

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A compound combination medicine for treating chronic obstructive pulmonary disease, comprising the following components in parts by weight: 60 parts of Codonopsis pilosula, 40 parts of prepared rhubarb, 100 parts of scutellaria baicalensis, 15 parts of Qinglong stone (stir-fried), 10 parts of Atractylodes macrocephala (stir-fried), Poria cocos 60 parts, ginger pinellia 90 parts, orange red 5 parts, ephedra 15 parts, almond 100 parts, agarwood 10 parts, chuanxiong 50 parts, ginger 100 parts, earthworm 100 parts.

[0017] Weigh the above fourteen herbs in parts by weight, add 5 times of water to soak for 60 minutes, decoct 3 times, 2 hours each time, filter, combine the filtrates, and concentrate the filtrate under reduced pressure to a relative density of 1.05g / L (60°C ) extract, add ethanol until the alcohol content is 70%, let it stand for 24 hours, take the supernatant, recover the ethanol until it has no alcohol smell and concentrate to an appropriate amount, add wate...

Embodiment 2

[0019] A compound combination medicine for treating chronic obstructive pulmonary disease, comprising the following components in parts by weight: 10 parts of Codonopsis pilosula, 50 parts of prepared rhubarb, 40 parts of scutellaria baicalensis, 60 parts of Qinglong stone (stir-fried), 50 parts of Atractylodes macrocephala (stir-fried), 20 parts of Poria cocos, 10 parts of ginger pinellia, 70 parts of orange red, 120 parts of ephedra, 10 parts of almond, 150 parts of agarwood, 10 parts of Chuanxiong, 5 parts of ginger, and 200 parts of earthworm. A total of fourteen herbs.

[0020] Weigh the above fourteen herbs in parts by weight, add 8 times of water to soak for 30 minutes, decoct for 3 hours, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.15g / L (60°C), add ethanol to contain alcohol The content is 80%, let it stand for 24 hours, take the supernatant, recover the ethanol until it has no alcohol smell and continue to co...

Embodiment 3

[0022] A compound combination medicine for treating chronic obstructive pulmonary disease, comprising the following components in parts by weight: 30 parts of Codonopsis pilosula, 20 parts of prepared rhubarb, 70 parts of Scutellaria baicalensis, 45 parts of Qinglong stone (stir-fried), 60 parts of Atractylodes macrocephala (stir-fried), 40 parts of Poria cocos, 100 parts of ginger pinellia, 35 parts of orange red, 90 parts of ephedra, 110 parts of almond, 100 parts of agarwood, 60 parts of Chuanxiong, 160 parts of ginger, and 40 parts of earthworm.

[0023] Weigh the above fourteen herbs in parts by weight, add 15 times the amount of water to soak for 45 minutes, decoct twice for 1 hour each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.10g / L (60°C) Add ethanol until the alcohol content is 60%, let it stand for 24 hours, take the supernatant, recover the ethanol until it has no alcohol smell and continue to c...

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PUM

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Abstract

The invention discloses a compound combination medicament for treating COPD, a preparation method and an application thereof. The compound combination medicament comprises the following components by weight: 10 to 60 parts of codonopsis pilosula, 20 to 50 parts of rhubarb, 40 to 100 parts of root of scutellaria, 15 to 60 parts of lapis chlorite (fried), 10 to 60 parts of bighead atractylodes rhizome (fried), 20 to 60 parts of poria cocos, 10 to 100 parts of pinellia, 5 to 70 parts of reddish orange, 15 to 120 parts of ephedra, 10 to 110 parts of almond, 10 to 150 parts of agilawood, 10 to 60 parts of liguisticum chuanxiong, 5 to 160 parts of ginger, and 40 to 200 parts of earthworm. The compound combination medicament provided in the invention is used for treating the COPD at the attack stage and is mainly used for treating spleen-deficiency and lung-heat COPD, wherein the symptoms of the spleen-deficiency and lung-heat COPD are cough, asthma, expectoration with yellow or white mucous sputum, dry excrement, dry mouth, abdominal fullness and distension, flat tongue with tooth mark on it, thin and yellow tongue coating, and wiry and slippery pulse. The compound combination medicament provided in the invention is used for treating the COPD at the attack stage and is mainly used for treating spleen-deficiency and lung-heat COPD, wherein the symptoms of the spleen-deficiency and lung-heat COPD are cough, asthma, expectoration with yellow or white mucous sputum, dry excrement, dry mouth, abdominal fullness and distension, flat tongue with tooth mark on it, thin and yellow tongue coating, and wiry and slippery pulse. The compound combination medicament has advantages of good curative effectiveness, short treating course, thorough treatment, no side effects and the like. Moreover, the compound combination medicament, which is made in a form of mixture, tablet, capsule, pellet, is easy to carry and to take.

Description

technical field [0001] The invention relates to a compound combination medicine, in particular to a compound combination medicine for treating chronic obstructive pulmonary disease (abbreviated as COPD) and a preparation method thereof, which is made from decoction pieces of traditional Chinese medicine. Background technique [0002] COPD has become an important public health problem due to its large number of patients, high mortality rate, and heavy social and economic burden. So far, there is no cure. Currently, the disease is the fourth leading cause of death in the world, and the World Bank / World Health Organization announced that by 2020, COPD will rank fifth in the world's economic burden of disease. In my country, COPD is also an important chronic respiratory disease that seriously endangers people's health, with a fatality rate of about 460 / 100,000. It is a collective term for a group of chronic airflow obstructive diseases, including chronic bronchitis and emphysem...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P11/00A61K35/64A61K33/26A61K35/62
Inventor 史锁芳刘志辉曹世宏
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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