Cancer treatments with radiation and immunocytokines
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- MERCK PATENT GMBH
- Publication Date
- 2011-09-21
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to methods of treating tumors and cancer cells by administering immunocytokines following radiation therapy. This combination of treatments can stimulate an immune response at both irradiated and non-irradiated sites, which is used to eliminate cancer cells that have spread from the primary tumor site. Furthermore, with this therapy, immunocytokine, preferably NHS-IL2(D20T) and NHS-IL12, can be administered at doses lower than the maximum tolerated dose, which reduces the side effects associated with immunocytokine therapy. Background technique
[0002] Effective treatment of diseases such as cancer requires a potent immune response from one or more effector cell types, such as natural killer (NK) cells, macrophages and T lymphocytes. However, existing cancer treatments, such as radiation therapy and chemotherapy, target rapidly dividing cells and thereby actually destroy immune cells. Furthermore, the environment of the...