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New application of aloperin in pharmacy

A technology of somarine and medicine, which is applied in the application field of sophorine in the preparation of medicines for treating digestive system cancer, can solve the problems of less pharmacological research and the like, and achieve the effects of excellent effect and improved stability.

Active Publication Date: 2011-10-19
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few pharmacological studies on its anti-cancer, especially anti-digestive system cancer

Method used

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  • New application of aloperin in pharmacy
  • New application of aloperin in pharmacy
  • New application of aloperin in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 The pharmaceutical composition for treating digestive system cancer, the dosage form is enteric-coated tablet

[0040] Prepared from the following ingredients:

[0041]

[0042]

[0043] The preparation method is:

[0044] 1. Place the prescribed amount of aloperine and microcrystalline cellulose in a fluidized bed; dissolve the prescribed amount of povidone in an appropriate amount of ethanol as a binder to prepare a soft material;

[0045] 2. Mix the prescribed amount of crospovidone, low-substituted hydroxypropyl cellulose, and starch, granulate with starch slurry, dry, and granulate, and mix the sized granules with the prepared soft material and the prescribed amount Magnesium stearate and silicon dioxide are mixed; Tablets; Obtained Aloperine Tablets;

[0046] 3. Dissolve the prescribed amount of hydroxypropyl methylcellulose in an appropriate amount of ethanol aqueous solution, then add the prescribed amount of propylene glycol, castor oil, and p...

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Abstract

The invention discloses the application of aloperin in the preparation of drugs for treating digestive cancers. An anticancer test of aloperin on a plurality of human digestive system cancer cell strains is carried out in the invention, and the result shows that aloperin has an obvious anticancer effect and has a more excellent effect than sophoridine, which is the well-recognized antineoplastic active component of Sophora alopecuroides. Therefore, aloperin can be used to prepare pharmaceutical compositions for treating digestive system cancers, so as to provide new therapeutic candidate drugs for patients with digestive system cancers. In addition, enteric coated tablets of the pharmaceutical compositions for treating digestive system cancers in the invention avoid aloperin to be released in stomach and destroyed by gastric acid, so as to raise the stability of aloperin as well as the drug concentration of aloperin on affecting positions.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to the application of aloperine in the preparation of drugs for treating digestive system cancer. Background technique [0002] Cancers of the digestive system, especially rectal cancers in the stomach, small intestine and large intestine, are high in my country and even in the world, becoming a major disease that threatens human health and life. By 2005, the World Health Organization estimated that the cases of death from cancer accounted for 13% of the total death cases, and maintained a rapid upward trend. Cancers of the digestive system can all be metastasized from ulcers or cancers in other parts, so the rate of cancer transformation is high, the range of lesions is wide, the course of the disease is protracted and repeated, and it is difficult to cure, which seriously affects the quality of life of patients. Clinically, Western medicine or surgical res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61K9/38A61K9/36A61K9/30A61P35/00A61P1/00
Inventor 蒋兆健刘洁瑜邓虹珠焦河玲李菁葛发欢
Owner GUANGZHOU HANFANG PHARMA
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