Cytidine disodium triphosphate injection liquid and preparation method thereof

Abstract

The invention relates to a medicinal preparation of a compound, and especially relates to a cytidine disodium triphosphate injection liquid, and a preparation method thereof. The preparation comprises cytidine disodium triphosphate, propylene glycol, and injection water. The preparation method comprises steps that: a small amount of injection water (with a temperature cooled to below 20 DEG C), propylene glycol and cytidine disodium triphosphate are fetched; cytidine disodium triphosphate is added to injection water, and is completely dissolved; propylene glycol is added to the solution, and is well-mixed by stirring; a 4% sodium hydroxide solution is slowly dropped into the solution, until the pH value of the solution is 8.6-.8.9; injection-use active carbon which takes 0.1% (g / ml) of the solution by volume is added to the solution, and the solution is stirred for 15 minutes; the solution is filtered, and injection water is added until a full dose is reached; and the solution is then processed through filtering, filling, sealing, lamp inspecting, and packaging. The injection liquid provided by the invention has advantages of simple formulation, simple technology, high production efficiency, strong medicine liquid stability, and the like.

Description

Technical field: [0001] The invention relates to a cytidine triphosphate disodium injection and a preparation method thereof, belonging to the technical field of medicines. Background of the invention: [0002] The main ingredient of cytidine triphosphate disodium injection is cytidine triphosphate disodium, which belongs to nucleotide derivatives, participates in the synthesis and metabolism of nucleic acid and phospholipids in the body, and promotes the synthesis of proteins. It can promote and regulate the synthesis and construction of nerve cells, glial cells and blood vessel wall cell membrane structures, and can resist nerve cell damage caused by excitatory amino acids and free radicals. Therefore, it can support the survival of the above-mentioned cells, enhance their activity, delay their death, improve their anti-injury, regeneration and repair capabilities, promote the re-growth of neurites, improve the nerve function of innervating blood vessels, and play an anti-...

AI Technical Summary

Problems solved by technology

[0003] The dosage forms of cytidine triphosphate disodium currently on the market are small-volume injections, infusions and powder injections, but because cytidine triphosphate disodium is unstable in aqueous solution and is easily hydrolyzed to form CDP and CMP, cytidine triphosphate disodium injection Easy to cause content loss during production and difficult to maintain stability during storage