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Traditional Chinese medicine preparation for improving climacteric metancholia and preparation method thereof

A technology of traditional Chinese medicine and syndrome, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of long medication time, large side effects, and increased incidence of breast cancer and endometrial cancer due to side effects.

Inactive Publication Date: 2012-03-14
GUANGZHOU JIAYUAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Sex hormone therapy is currently the most effective therapy, but its side effects are also very large, and its medication time is longer, and the side effects will increase the incidence of breast cancer, endometrial cancer, etc., so it is generally not used for patients with mild symptoms

Method used

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  • Traditional Chinese medicine preparation for improving climacteric metancholia and preparation method thereof
  • Traditional Chinese medicine preparation for improving climacteric metancholia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 Capsules of the present invention are prepared (taking ten times the ratio of raw materials as an example)

[0016] Take by weighing 120 parts of each crude drug Ai Shi, 120 parts of Shayuanzi, 180 parts of Star Anise, 180 parts of Lily, and 120 parts of Baiwei by weighing the following weight ratios;

[0017] Ai Shi, Shayuanzi, Star Anise Lotus, Lily, and Baiwei in the above weight ratio are soaked in 9 times the amount of water for 3 hours, heated and decocted for 1.5 hours, filtered, and medicinal residues are added with 7 times the amount of water, heated and decocted for 1 hour, filtered , combine the two filtrates, let stand for 1 hour, and pour out the supernatant; after the supernatant is concentrated in a rotary evaporator to a relative density of 1.1, it enters a spray dryer, and the air inlet temperature is controlled at 140°C, and the outlet air temperature is 110°C , the atomizer rotation speed is 50 rpm, and the feed rate is 5ml / min to obtain ...

Embodiment 2

[0018] Embodiment 2 Tablet preparation of the present invention (taking ten times of raw material proportioning amount as example)

[0019] Take by weighing 120 parts of each crude drug Ai Shi, 120 parts of Shayuanzi, 180 parts of Star Anise, 180 parts of Lily, and 120 parts of Baiwei by weighing the following weight ratios;

[0020] Ai Shi, Shayuanzi, Star Anise Lotus, Lily, and Baiwei in the above weight ratio are soaked in 9 times the amount of water for 3 hours, heated and decocted for 1.5 hours, filtered, and medicinal residues are added with 7 times the amount of water, heated and decocted for 1 hour, filtered , combine the two filtrates, let stand for 1 hour, and pour out the supernatant; after the supernatant is concentrated in a rotary evaporator to a relative density of 1.1, it enters a spray dryer, and the air inlet temperature is controlled at 140°C, and the outlet air temperature is 110°C , the atomizer rotating speed is 50 rpm, and the feed rate is 5ml / min to obt...

experiment example 1

[0021] Experimental example 1 sedative hypnotic pharmacodynamics experiment

[0022] Medicine preparation: weigh 12 parts of Aishi, 12 parts of Shayuanzi, 18 parts of Star Anise, 18 parts of Lily, and 12 parts of Baiwei according to the weight ratio. Add 9 times the amount of water to soak for 3 hours, heat and decoct for 1.5 hours, filter, add 7 times the amount of water to heat and decoct for 1 hour, filter, combine the two filtrates, let stand for 1 hour, pour out the supernatant; The supernatant was concentrated under reduced pressure, and different concentrations were prepared according to the needs of the test drug for later use.

[0023] Methods: 60 15-month-old Kunming mice were randomly divided into 5 groups, 12 in each group, respectively: control group, positive control group (Xiaoyao Pill), high-dose group, middle-dose group and low-dose group of the present invention . Wherein, the mice in the high-dose group, the middle-dose group and the low-dose group of the ...

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Abstract

The invention discloses a traditional Chinese medicine preparation for improving climacteric metancholia and a preparation method thereof, and belongs to the field of traditional Chinese medicine. Raw materials of traditional Chinese medicines including fruit of argy wormwood, semen astragali complanati, dysosma pleiantha, lily and cynanchi root are prepared into an active component; then the active component and commonly used medical accessories are prepared into an oral preparation. The traditional Chinese medicine preparation can improve climacteric clinic symptoms and has good treatment effect on female climacteric metancholia.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation for improving menopausal syndrome and a preparation method thereof, belonging to the field of traditional Chinese medicines. technical background: [0002] Menopause is a necessary period for every woman before and after menopause. Women's menopause has different inducing factors, among which the syndromes that appear before and after natural menopause are called menopausal syndrome. According to statistics, women over the age of 45 in my country account for more than 10% of the national population, and more than 60% of them have climacteric syndrome in various degrees. [0003] Before and after menopause, due to changes in endocrine levels in the body, a system of symptoms will appear, such as flushing, hot flashes, sweating, palpitations, headaches, emotional irritability, irritability, depression, suspiciousness, insomnia, etc. [0004] The method for the treatment of menopausal s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8967A61P15/12
Inventor 王素侠樊婷婷何岚
Owner GUANGZHOU JIAYUAN PHARMA TECH
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