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Chinese medicinal composition for reversing multi-drug resistance of tumor and preparation method and application thereof

A multi-drug resistance and composition technology, which is applied in drug combinations, anti-tumor drugs, pharmaceutical formulations and other directions to achieve significant tumor multi-drug resistance, improve curative effect, and reverse tumor multi-drug resistance.

Inactive Publication Date: 2014-07-02
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Chinese invention patent CN200710070320.4 discloses "the use of curcumin in the preparation of tumor multidrug resistance preventive agents", and Chinese invention patent CN200710143393.1 discloses "the application of artemisinin in the preparation of anti-tumor multidrug resistance drugs" ; but there are fewer reports about the traditional Chinese medicine composition as a tumor multidrug resistance reversal agent at present

Method used

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  • Chinese medicinal composition for reversing multi-drug resistance of tumor and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of traditional Chinese medicine composition for reversing tumor multidrug resistance:

[0029] (1) Weigh 100g of Shandougen, 300g of Baiying, 100g of Kudingcha, 300g of Platycladus orientalis and 100g of Bougainvillea, mix and add 9 times the total weight of each Chinese medicine raw material, soak in water for 2 hours, heat and decoct for 1.5h, Pour out the decoction liquid; add the medicine dregs and add 8 times the total weight of each Chinese medicine raw material to heat and cook for 1.5 hours, pour out the decoction liquid, combine and filter the decoction liquid obtained from the two decoctions to obtain the clear liquid;

[0030] (2) When the clear liquid is concentrated to a relative density of 1.05, it is sent to a spray dryer for spray drying. The inlet air temperature is controlled to 140°C, the outlet air temperature is 100°C, the atomizer speed is 50 rpm, and the feeding speed At 3ml / min, 30 grams of spray-dried powder is obtained; the spray-dried p...

Embodiment 2

[0032] Preparation of traditional Chinese medicine composition for reversing tumor multidrug resistance:

[0033] (1) Weigh 300g of Shandougen, 100g of Baiying, 300g of Kudingcha, 100g of Platycladus orientalis and 300g of Bougainvillea, which are the raw materials of Chinese medicine. After mixing, add 10 times the total weight of each Chinese medicine raw material to soak for 3 hours, heat and decoct for 2 hours , Pour out the decoction liquid; add 8 times the total weight of each traditional Chinese medicine raw material to the medicine residue and heat and decoct for 1 hour, pour out the decoction liquid, combine and filter the decoction liquid obtained from the two decoctions to obtain the clear liquid;

[0034] (2) When the clear liquid is concentrated to a relative density of 1.05, it enters the spray dryer, the inlet air temperature is controlled at 140°C, the outlet air temperature is 100°C, the atomizer speed is 50 revolutions / min, and the feed rate is 3 ml / min. 50 grams ...

Embodiment 3

[0036] Preparation of traditional Chinese medicine composition for reversing tumor multidrug resistance:

[0037] (1) Weigh 120g Shandougen, 120g Baiying, 180g Kudingcha, 120g Platycladus leaf, and 180g Bougainvillea, which are the raw materials of Chinese medicine. After mixing, add 9.5 times the total weight of each Chinese medicine raw material, soak for 2.5 hours, heat and decoct for 2h , Pour out the decoction liquid; add the medicine residue and add 9 times the total weight of each Chinese medicine raw material to heat for 1 hour, pour out the decoction liquid, combine and filter the decoction liquid obtained from the two decoctions to obtain the clear liquid;

[0038] (2) When the clear liquid is concentrated to a relative density of 1.06, enter the spray dryer, the inlet air temperature is controlled at 160°C, the outlet air temperature is 110°C, the atomizer rotation speed is 60 revolutions / min, and the feed rate is 5 ml / min. 30 grams of dry powder; the spray-dried powder ...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses a Chinese medicinal composition for reversing multi-drug resistance of tumor and a preparation method and an application thereof. The Chinese medicinal composition is made of the following Chinese medicinal herb raw materials by weight part: 10 to 30 parts of subprostrate sophora, 10 to 30 parts of climbing nightshade, 10 to 30 parts of broadleaf holly leaves, 10 to 30 parts of Cacumen Biotae and 10 to 30 parts of Bougainvillea spectabilis Willd.; the above Chinese medicinal raw materials are immersed in the water for 2 to 3 hours after being mixed, decocted liquid is poured out after the raw materials are heated and decocted, then water is added into the raw materials to be decocted, the decocted liquid is poured out, the decocted liquid is filtered after being mixed, the obtained clear liquid is concentrated, atomized, dried and screened after being pulverized to obtain the Chinese medicinal composition for reversing the multi-drug resistance of tumor. Blood serum of the Chinese medicinal composition is combined with adriamycin to use, 50% inhibitory concentration of adriamycin on leukemia cell adriamycin persister is remarkably reduced, the reversing times are 2.87 to 4.37 and is positively correlated to the concentration, and a remarkable effect on reversing the multi-drug resistance of tumor can be realized.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for reversing tumor multi-drug resistance, and a preparation method and application thereof. technical background [0002] Multidrug resistance (MDR) of tumor cells to antitumor drugs is a common factor leading to the failure of tumor chemotherapy. At present, the prevalence of tumors in China is on the rise, and 90% of the deaths of tumor patients are affected by the drug resistance of tumor cells to varying degrees. Therefore, it is necessary to develop a new generation of drug resistance reversal agents. It is known that certain traditional Chinese medicines have calcium antagonism, and the drug has a milder effect, and can improve the effect of chemotherapy in reversing MDR, and has good application and development prospects. [0003] The results of the study indicate that multiple mechanisms are involved in the formation of multi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61P35/00
Inventor 蔡宇张荣华
Owner JINAN UNIVERSITY
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