Anticoccidial compound, and preparation method and use thereof

A compound, anti-coccidial technology, applied in organic chemistry, anti-infective drugs, drug combinations and other directions, can solve problems such as parasite drug resistance, and achieve the effects of low cost, solving drug resistance problems, and high yield

Inactive Publication Date: 2012-04-11
CHINA ANIMAL HUSBANDRY IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term use of these drugs will easily lead to drug resistance of parasites, so there is an urgent need for new drugs to appear. With the development of animal husbandry, aquaculture and public health security, the mark

Method used

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  • Anticoccidial compound, and preparation method and use thereof
  • Anticoccidial compound, and preparation method and use thereof
  • Anticoccidial compound, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1: Synthesis of 4-Dimethoxymethylpyridine

[0031]

[0032] operate:

[0033] A 250mL three-necked flask was equipped with a dropping funnel and a condenser. In the bottle, 4-pyridinecarbaldehyde (11g, 0.1mol) was dissolved in 100mL of methanol, and trimethyl orthoformate (30mL) was slowly added dropwise, and the resulting mixture was heated to reflux for 3h.

[0034] Post-processing:

[0035] After the reaction solution was evaporated to dryness, 200 mL of water was added, extracted with ethyl acetate, and the organic phase was dried and evaporated to dryness. After adding some diethyl ether, a solid precipitated out, filtered, and the filtrate was evaporated to dryness to obtain the product. 11.3 g of the product was obtained, with a yield of 72%.

[0036] 1 HNMR (CDCl 3 ): 8.58-8.60 (m, 2H), 7.36 (m, 2H), 5.26 (d, 1H), 3.30 (d, 6H).

[0037] The second step: Synthesis of 1-bromomethyl-4-fluorobenzene

[0038]

[0039] operate:

[0040] 250mL three-n...

experiment example

[0077] EXPERIMENTAL EXAMPLE The preventive effect test of three kinds of drugs on Eimeria tenella artificially infected chicken

[0078] 1. Experimental materials

[0079] 1. Test drug

[0080] 1) Test drug and dose: three test drugs, respectively B 1 -1, B 1 -2, B 1 -3,

[0081] The dose is 100mg / Kg (100mg test drug per kilogram of feed).

[0082] Test Compound Structural Formula

[0083]

[0084] B 1 -1 B 1 -twenty three 1 -3

[0085] 2) Test chickens: 100 freshly hatched AA broilers were purchased from the hatchery of the Institute of Animal Husbandry, Chinese Academy of Agricultural Sciences and Beijing Huadu Broiler Farm. After hatching, they were raised in flame-sterilized wire cages, with free access to food and water until they were 10 days old.

[0086] 2. Feed: feed broiler chickens full-price compound feed, and the feed is baked at 80°C for 2 hours before use to eliminate possible coccidia.

[0087] 3. Chicken cages for raising chickens: Before raisin...

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PUM

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Abstract

The invention relates to an anticoccidial compound shown as a formula (I) and a preparation method therefore, wherein R is selected from Me, H or Cbz. The anticoccidial compound provided by the invention can effectively solve the problem of drug resistance of the existing coccidiostat and can exert an important function on the treatment of livestock and poultry, particularly in the aspect of coccidial infection of chicken; furthermore, the main raw materials used in the preparation method are very easy to get on the market and are cheap, further, the technological operation is simple, no riskexists, and meanwhile, the method has the characteristics of low cost, high yield and the like, so that the method is applicable to enlargement and industrial production and has an industrialization value.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to the prevention and treatment of livestock and poultry parasites, more specifically, to an anticoccidial compound and its preparation method and application. Background technique [0002] Coccidiosis is one of the main causes of livestock and poultry morbidity and death. Failure to effectively control coccidiosis will bring huge losses to the livestock and poultry breeding industry. Since the 1980s, livestock and poultry have gradually developed great drug resistance to the existing coccidial drugs, and the demand for new low-priced broad-spectrum drugs has become very urgent. [0003] Coccidiosis is a parasitic disease that can cause severe losses in poultry meat and egg production. The parasite multiplies in the small intestine causing tissue damage, reducing feed intake and absorption of nutrients in the feed, causing dehydration and death of the chicken. After the chicken ...

Claims

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Application Information

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IPC IPC(8): C07D401/14A61K31/4545A61P33/02
Inventor 刘金华郭以猛李新乐齐鹏马佳颖王峥
Owner CHINA ANIMAL HUSBANDRY IND
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