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Pentacyclic triterpene saponin and application thereof

A technology of pentacyclic triterpenoids and saponins, which is applied in the field of medicine to achieve the effect of preventing and treating senile dementia

Inactive Publication Date: 2012-05-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound in the present invention is a new compound, and there is no related report

Method used

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  • Pentacyclic triterpene saponin and application thereof
  • Pentacyclic triterpene saponin and application thereof
  • Pentacyclic triterpene saponin and application thereof

Examples

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Embodiment 1

[0031] Example 1. Compound Preparation

[0032] The dried root of Pulsatilla chinensis (100 g) was pulverized, extracted with 50% ethanol aqueous solution at 80° C. for 4 h, and the extract was concentrated under reduced pressure to obtain a concentrated solution. The concentrated solution was successively extracted with 100 mL of petroleum ether, dichloromethane and n-butanol, respectively. Extracted twice, the n-butanol extract was concentrated and then subjected to D101 macroporous adsorption resin column chromatography, followed by gradient elution with water, 30% ethanol, 50% ethanol, 70% ethanol and 95% ethanol. The 50% and 70% ethanol eluents were combined, concentrated under reduced pressure, dried, subjected to silica gel column chromatography, eluted with dichloromethane-methanol-water (9:1:0.1-7:3:0.3), and then prepared HPLC separation and purification, using methanol-acetonitrile-water (3:2:3) as mobile phase elution to obtain the compound.

[0033] Structure Ide...

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Abstract

The invention relates to the medical technical field, in particular to a pentacyclic triterpene compound which is separated to be obtained from a ranunculaceae plant of pulsatilla cernua (Thunb.) Bercht.et Opiz, and the chemical structural formula is shown in the accompanying drawing, wherein glc, rha and ara respectively represent beta-D-glucopyranose, alpha-L-pyrane rhamnose and alpha-L-pyrane arabinose, and the compounds A and B are respectively a new compound. Cell experiments in vitro show that the compound has a remarkable protection function to neuroblastoma cell strain SH-SY5Y induced by A beta (25-35). The compound disclosed by the invention has the advantages of simpleness in preparation and remarkable activity. The invention provides the new compound for preventing and curing AD (Alzheimer's Disease). In the invention, the glc, rha and ara respectively represent beta-D-glucopyranose, alpha-L-pyrane rhamnose and alpha-L-pyrane arabinose.

Description

technical field [0001] The invention relates to the technical field of medicine, relates to pentacyclic triterpenoid saponins and uses thereof, in particular to a kind of pentacyclic triterpenoids isolated from Ranunculaceae plant Pulsatilla cernua (Thunb.) Bercht. et Opiz. The compound and its application in the medicament for preventing and treating senile dementia (Alzheimer's disease, AD). Background technique [0002] Alzheimer's disease (AD) was first discovered in 1906 by neuropathologist Alzheimer's and was named after it. AD is a diffuse central nervous system degenerative disease, a common senile neurodegenerative disease characterized by progressive cognitive impairment, intellectual decline and personality changes, accounting for about 50% to 60% of all dementias. According to reports, about 3% of the elderly aged 65 to 74 have AD, the prevalence rate of the elderly aged 75 to 84 is 19%, and the prevalence of AD patients in the elderly > 85 years old is highe...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/08A61K31/704A61P25/28
Inventor 许永男刘建宇
Owner SHENYANG PHARMA UNIVERSITY
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