Desloratadine critrate disodium particles and preparation method for same

Abstract

The invention discloses desloratadine critrate disodium particles. Based on 100 percent, the desloratadine critrate disodium particles comprise the following raw materials in percentage by weight: 0.1 to 2 percent of desloratadine critrate disodium, 20 to 90 percent of filler, 1 to 10 percent of sweetener, 0.1 to 5 percent of PH conditioner, 0.1 to 2 percent of essence and 0 to 0.05 percent of food coloring, wherein the desloratadine critrate disodium serves as an active ingredient; and the filler, the sweetener, the PH conditioner, the essence and the food coloring serve as minor ingredients. The prepared desloratadine critrate disodium particles have good mouth-feel, and are fresh red, attractive, convenient to take, fast in absorption and high in bioavailability; and a child can compliantly take the particles.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to desloratadine citrate granules and a preparation method thereof. Background technique [0002] Desloratadine citrate is a non-sedating long-acting histamine antagonist with potent and selective antagonism of peripheral H, receptor action and anti-inflammatory effects. It is mainly used for the rapid relief of symptoms related to allergic rhinitis (allergic rhinitis), such as sneezing, runny nose, and itchy nose; congestion / stuffiness of nasal mucosa; and itchy, tearing, and congestion of eyes; itchy palate, and cough. It is also used to relieve symptoms associated with chronic idiopathic urticaria, such as itching, and to reduce the number and size of urticaria. [0003] Currently, the dosage forms for clinical selection mainly include tablets, capsules and the like. The absorption of tablets in the body must go through processes such as disintegration and dissolution before...

AI Technical Summary

Problems solved by technology

The absorption of tablets in the body must go through processes such as disintegration and dissolution before they can be absorbed into the blood circulation. However, in the production process of tablets, it is often difficult to disintegrate due to excipients and processes, and the drug release is not complete, so that the drug cannot achieve the expected therapeutic effect. Effect

Capsules are mainly composed of gelatin, which will become sticky when exposed to water, and tend to stick in the mouth when taking it, making it difficult to swallow

[0004] Due to the incomplete development of various body organs and poor swallowing ability of children, when taking tablets and capsules, it is very easy for capsules and tablets to block the trachea or get stuck in the throat.

And because most medicines have obvious bitter taste, it is not easy to be accepted by children, most parents use the method of forced irrigation, which is very likely to cause the child's tracheal blockage and cause danger

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