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Dry suspension of cefpodoxime proxetil composition and preparation method thereof

A technology of cefpodoxime axetil and dry suspension, applied in the field of medicine, can solve problems such as unfavorable swallowing, poor patient taking compliance, poor dissolution and the like

Inactive Publication Date: 2012-07-04
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, most of the cefpodoxime axetil preparations are tablets, which are not conducive to swallowing, and the dissolution rate is poor, resulting in poor patient compliance

Method used

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  • Dry suspension of cefpodoxime proxetil composition and preparation method thereof
  • Dry suspension of cefpodoxime proxetil composition and preparation method thereof
  • Dry suspension of cefpodoxime proxetil composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: dry suspension of cefpodoxime axetil composition of the present invention

[0019]

[0020] Preparation method: take cefpodoxime axetil and sucrose to pass through a 100-mesh sieve respectively, and take hypromellose and xanthan gum to pass through a 120-mesh sieve respectively; take 50 g of pulverized cefpodoxime axetil and 660 g of pulverized sucrose, mix evenly, add 200g of 95% ethanol is used to make soft materials, and then granulated with a 40-mesh sieve. The prepared wet granules are dried at 45-50°C for 30 minutes, and granulated through a 40-mesh sieve; Mix with pulverized xanthan gum 71g to obtain.

Embodiment 2

[0021] Embodiment 2: the antibacterial effect of cefpodoxime axetil composition dry suspension of the present invention

[0022] Inoculate one piece of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella, Proteus mirabilis, and Streptococcus pneumoniae in 1 mL of broth medium, and culture them at 37°C for 8-9 hours to make the meat of the bacteria. soup suspension. Get 12 sterile test tubes, every six as a batch, divide into two batches, add the broth suspension of above-mentioned six kinds of bacteria respectively in each batch, then add 6 parts of 1mL containing 0.5mg cefpodoxime axetil composition of the present invention The dry suspension broth culture medium was added to a batch of broth suspensions of six kinds of bacteria respectively, and the broth culture medium containing 0.5 mg of the existing cefpodoxime axetil tablet was treated in the same way as above, and then cultivated at 37 ° C for 24 hours, and observed The results are shown in...

Embodiment 3

[0026] Example 3: Clinical research on the antibacterial effect of the dry suspension of the cefpodoxime axetil composition of the present invention

[0027] 2000 patients with upper respiratory tract infection, lower respiratory tract infection, skin and soft tissue infection, and genitourinary system caused by sensitive bacteria were randomly divided into treatment group A, treatment group B and control group. Treatment group A is given existing cefpodoxime axetil tablet on the basis of routine treatment, and treatment group B is given the dry suspension of cefpodoxime axetil composition prepared by the embodiment of the present invention 1 on the basis of routine treatment, every day 2 times, 100 mg each time, 7 days of treatment, the control group was given cephalexin. The bacterial clearance rate of each group was counted, and the results are shown in Table 2

[0028] Table 2 Antibacterial effect clinical research

[0029] control group

[0030] Sig...

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Abstract

The invention relates to the technical field of medicine and pharmacy and discloses a dry suspension of cefpodoxime proxetil composition and a preparation method thereof. The dry suspension of cefpodoxime proxetil composition is made from the following raw materials in parts by weight: 50 of cefpodoxime proxetil, 60 of sucrose, 71 of hydroxypropyl methylcellulose, 71 of xanthan gum and 200 of 95% ethanol. The 95% ethanol can serve as a pharmaceutical humectant for preventing drugs from caking and increasing dissolubility of drugs. The stability and safety of traditional Chinese medicines in the dry suspension of cefpodoxime proxetil composition are substantially not changed, to achieve safety and efficacy of medication. The trials show that the dry suspension of cefpodoxime proxetil composition has strong antimicrobial effect and good stability. The dry suspension of cefpodoxime proxetil composition can be widely applied to treatment of upper/lower respiratory infections, skin and soft tissue infections, urogenital system infections and pediatric infections.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a dry suspension of cefpodoxime axetil composition and a preparation method thereof. Background technique [0002] Antimicrobial infection drugs are the second largest class of drugs in the global pharmaceutical market today, and β-lactam antibiotics are the most clinically used, most widely used, most diverse, best curative effect and highest evaluation class Antibiotics occupy an important position in anti-infective drugs, accounting for 58.7% of the total sales of antibiotics in the world. Among them, cephalosporin series products account for about 70%. It can be seen that in the pharmaceutical market, cephalosporins occupy an important position in β-lactam antibiotics and even anti-infective drugs. [0003] Among various cephalosporins, oral cephalosporins are popular among medical staff and patients because of their convenience and cost-effectiveness. In 1990, the output ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/546A61K47/38A61P31/04
Inventor 冯长银王全园蒋燕杰
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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