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Chinese medicinal composition for treating senile dementia and preparation method and application thereof

A composition and senile technology, applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of large toxic and side effects, the cause of AD is not very clear, and the efficacy of western medicine is uncertain.

Inactive Publication Date: 2012-07-04
SHANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the uncertain curative effect of western medicine, high toxicity and side effects, and the unclear etiology of AD, it is still very difficult for modern medicine to find chemically synthesized drugs that are truly effective in the prevention and treatment of AD in the near future.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Recipe: Turtle Shell 25g, Bovine Spinal Cord 25g, Rehmanniae Rehmanniae 18g, Yizhiren 18g, Polygala 18g, Ginseng 13g, Cornus officinalis 8g, Shichangpu 8g.

[0052] Preparation: decoct the above-mentioned crude drug twice, add 8 times of water each time, and make a decoction for taking.

Embodiment 2

[0054] Formula: turtle shell 35kg, bovine spinal cord 35kg, Rehmannia glutinosa 22kg, Yizhiren 22kg, polygala 22kg, ginseng 17kg, dogwood 12kg, calamus 12kg.

[0055] Preparation: Take Rehmannia glutinosa, Yizhiren, Polygala and Shichangpu, add 10 times the amount of water to decoct twice, filter, combine the filtrate, cool to room temperature, centrifuge, concentrate the supernatant into a clear paste, and set aside; take dogwood and ginseng , Turtle shells are crushed into coarse powder; Boil the bovine spinal cord in boiling water, remove the skin, mix well with the above coarse powder, dry, grind into fine powder, and set aside; Mix the above clear paste with fine powder, add the conventional auxiliary materials required for the preparation , compressed into tablets.

Embodiment 3

[0057] Formula: Turtle Shell 35kg, Bovine Spinal Cord 35kg, Rehmanniae Rehmanniae 18kg, Yizhiren 18kg, Polygala 18kg, Ginseng 17kg, Dogwood 12kg, Shichangpu 12kg.

[0058] Preparation: Take Rehmannia glutinosa, Yizhiren, Polygala and Shichangpu and add 8 times the amount of water to decoct twice, filter, combine the filtrate, cool to room temperature, centrifuge, and concentrate the supernatant to a relative density of 1.20-1.25 (80°C) Take the cornus officinalis, ginseng, and turtle shell and grind them into coarse powder; boil the bovine spinal cord in boiling water, remove the skin, mix well with the above coarse powder, dry, grind into fine powder, and set aside; mix the above clear paste with Mix fine powder, add conventional auxiliary materials required for preparation, and fill into capsules.

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Abstract

The invention discloses a Chinese medicinal composition for treating senile dementia, in particular relates to a Chinese medicinal composition and a preparation method thereof, and belongs to the field of Chinese medicines. The Chinese medicinal composition is prepared from the following Chinese herbal medicines: turtle shell, bovine spinal cord, rehmannia root, sharpleaf galangal fruit, thinleaf milkwort root-bark, ginseng, common macrocarpium fruit and grassleaf sweelflag rhizome in a certain weight ratio through an appropriate extraction and refining process. Animal experiments indicate that the Chinese medicinal composition can improve super oxygen dehydrogenises (SOD) vigor in blood serum of model mice and reduce methane dicarboxylic aldehyde (MDA) content in the blood serum of the model mice, has an improvement effect on the learning memory obstacle of alzheimer's disease (AD) mice, and has a certain treatment effect on senile dementia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating senile dementia, in particular to a traditional Chinese medicine composition and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Alzheimer's disease, namely Alzheimer's disease (AD), is a progressive and fatal neurodegenerative disease. Neuropsychiatric symptoms and behavioral disturbances. Prevalence research shows that the number of Alzheimer's cases in the United States in 2000 was 4.5 million, and the percentage of Alzheimer's disease patients will increase by 2 times for every 5 years of age increase. The prevalence rate is 1%, compared with 30% in the 85-year-old population. Although the condition can appear at any age, it usually appears between the ages of 60-70. When people are diagnosed with the disease, they usually live for 5-10 years, but new research shows that the survival rate of the disease is declin...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P25/28
Inventor 郭蕾柴金苗王玉璧张俊龙
Owner SHANXI UNIV OF CHINESE MEDICINE
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