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Quick screening method and quick semi-quantitative determination method of chlorphenamine maleate doped in Chinese patent drugs and health-care food

A technology of chlorpheniramine acid and health food, which is applied in the direction of material analysis by observing the influence of chemical indicators, and analysis by making materials undergo chemical reactions, etc., which can solve the problems of long processing time, expensive instruments, and separation effects. Large impact and other issues, to achieve the effect of high accuracy, strong specificity, and wide application range

Inactive Publication Date: 2012-07-11
深圳市药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantages of this method are: (1) the chromatographic resolution is low, the composition of traditional Chinese medicine preparations is complicated, and there are many interference factors, and it is easy to misjudge some coexisting components as chlorpheniramine maleate components. If the chromatographic shift value is close to that of the component to be measured, it will interfere with the detection of the target component
(2) The time for chromatographic development and drying is long, which is not enough to meet the requirements of rapid determination
(3) Thin-layer chromatography plates need to be dried and stored in a dry place, and the ambient temperature and humidity have a great influence on the separation effect
(4) A fixed place is required, and it is not suitable for on-site testing with high mobility
Shortcoming is: (1) instrument is expensive, and sample pretreatment time is long, and chromatographic column is polluted easily, and analysis cost height; It is easy to make wrong judgments; (3) The instrument has high requirements on the use environment and needs to be placed fixedly, so it is not suitable for on-site detection with large fluidity
[0016] At present, there is no feasible method for rapid screening of chlorpheniramine maleate using physical and chemical reactions in the Chinese patent medicine and health food industry. Sensitive rapid screening method, rapid analysis of samples at the supervision site, providing timely evidence for the supervision of Chinese patent medicines and health food, it is very necessary to crack down on counterfeiting by criminals and ensure the safety of people's medication

Method used

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  • Quick screening method and quick semi-quantitative determination method of chlorphenamine maleate doped in Chinese patent drugs and health-care food
  • Quick screening method and quick semi-quantitative determination method of chlorphenamine maleate doped in Chinese patent drugs and health-care food
  • Quick screening method and quick semi-quantitative determination method of chlorphenamine maleate doped in Chinese patent drugs and health-care food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Commercially available health food A (tablets, the labeled dosage is 2 tablets each time, and the test results of high performance liquid chromatography contain 0.7mg of chlorpheniramine maleate in each tablet of this product)

[0075] Take one piece of this product, crush it, put it in a sample tube, add 10ml of water, shake for 1min, filter, take 2ml of the filtrate as the test solution; take 0.2g of chromotropic acid, add 100ml of water to dissolve it, and use it as a color reagent Add 0.5ml of chromogenic reagent to the test solution, add 0.1ml of acetic acid-sodium acetate buffer solution (PH=4.5) to the test solution, shake for 30s, then add 5ml of dichloromethane, shake and mix evenly, After layering, the dichloromethane layer turns into a color between pink and light pink, so it can be judged that the sample contains illegally added chlorpheniramine maleate components, and at the same time, the content of chlorpheniramine maleate is 0.2 Between ~0.1mg, multiplie...

Embodiment 2

[0077] Commercially available health food B (capsules, the labeled dosage is 1 capsule each time, and the test result of high performance liquid chromatography is 1.16mg of chlorpheniramine maleate per capsule of this product)

[0078] Take one grain of this product, put it in a sample tube, add 10ml of water, shake for 1min, filter, take 2ml of the filtrate as the test solution; take 0.2g of chromotropic acid, add 100ml of water to dissolve it, and use it as a color reagent ; Add 0.5ml of chromogenic reagent to the test solution, add 0.1ml of acetic acid-sodium acetate buffer solution (PH=4.5) to the test solution, shake for 30s, then add 5ml of dichloromethane, shake and mix well, let stand After layering, the color of the dichloromethane layer becomes between pink and pink, so it can be judged that the sample contains illegally added chlorpheniramine maleate ingredients, and at the same time, the content of chlorpheniramine maleate is between 0.4-0.2 mg, multiplied by the d...

Embodiment 3

[0080] Commercially available health food C (capsules, the labeled dosage is 2 capsules each time, the test results of high performance liquid chromatography for this product are 1.04mg of chlorpheniramine maleate per capsule)

[0081] Take one grain of this product, put it in a sample tube, add 10ml of water, shake for 1min, filter, take 2ml of the filtrate as the test solution; take 0.2g of chromotropic acid, add 100ml of water to dissolve it, and use it as a color reagent ; Add 0.5ml of chromogenic reagent to the test solution, add 0.1ml of acetic acid-sodium acetate buffer solution (PH=4.5) to the test solution, shake for 30s, then add 5ml of dichloromethane, shake and mix well, let stand Put the layers, the dichloromethane layer turns pink, so it can be judged that the sample contains illegally added chlorpheniramine maleate components, and at the same time, the content of chlorpheniramine maleate is close to 0.2mg, multiplied by the dilution factor = 5 , It is judged tha...

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Abstract

The invention relates to a detection method of chlorphenamine maleate components, and particularly discloses a quick screening method of chlorphenamine maleate doped in Chinese patent drugs and health-care food. The method comprises the following steps of: (1) extracting chlorphenamine maleate in Chinese patent drugs or health-care food with water; (2) adding a chromotropic acid water solution color reagent into the extracting solution; (3) adding an acidic buffer salt solution; and (4) adding dichloromethane into the solution for extracting, absorbing the dichloromethane layer, and observing the color. The inspection method disclosed by the invention is quick, simple and convenient, has the advantages of strong specificity, high accuracy, rapid response and wide range of application, is suitable for inspecting whether chlorphenamine maleate is doped in Chinese patent drugs and health-care food on the site, and can initially judge the content of chlorphenamine maleate.

Description

technical field [0001] The invention relates to a rapid screening method and a rapid semi-quantitative determination method for chlorpheniramine maleate components, specifically for detecting Chinese patent medicines and health foods, especially for detecting antirheumatic or sedative Chinese patent medicines and health foods Whether to add chlorpheniramine maleate, and the method for semi-quantitative determination of added chlorpheniramine maleate. Background technique [0002] At present, there are many kinds of Chinese patent medicines for treating rheumatism and a variety of sedative and tranquilizing health foods on the market, and the ingredients are mainly pure plants or pure Chinese medicines, and do not contain western medicine ingredients or hormone ingredients with sleep-promoting effects. [0003] Chlorpheniramine, also known as chlorpheniramine, is a drug used for allergic symptoms, belonging to the first generation of histamine H1 receptor antagonists (also kn...

Claims

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Application Information

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IPC IPC(8): G01N21/78
Inventor 肖丽和韩东岐王铁杰关潇滢殷果王珏闫研黎雪清
Owner 深圳市药品检验所
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