Application of rat model with depression related to chronic pain in researching on action mechanism and targets of antidepressant on pain

Abstract

The invention discloses application of a rat model with depression related to a chronic pain in researching on an action mechanism and targets of an antidepressant on pain. According to the model, lumbar 5 spinal nerve of a rat is ligated to cause distinct mechanical hyperalgesia and abnormal pain, accomplished with depression symptom. Then the ligation is released, and the abnormal pain behaviors of animals gradually disappear, but the psychiatric symptoms continue to exist. The depression model prepared by the invention can simulate a clinical phenomenon which is that pains disappear but emotional disorders still exist after treatment for the chronic pain patients, and then the action mechanism and the targets of the antidepressant on pain is understood from the source.

Description

technical field [0001] The invention belongs to the production of medical animal models, in particular to the application of a chronic pain-related depression rat model in the study of the mechanism of action and target of antidepressants on pain, which can be used to observe and analyze pain-related symptoms in rats. Behavioral and morphological changes after depression. Background technique [0002] Pain refers to "the unpleasant feeling and emotional experience brought about by real or potential tissue damage or similar situations", which is the most primitive, common and earliest subjective feeling experienced by human beings, such as toothache, headache, joint pain, etc. . Pain is divided into acute pain and chronic pain. Acute pain occurs at the moment of tissue damage, alerting the body to the threat of damage, and often has a protective effect, which is what people often call "good pain". Chronic pain refers to pain that lasts for days, weeks or even longer, such ...

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Problems solved by technology

[0006] However, there are often such problems or defects when using the single lumbar spinal nerve ligation model to study the abnormal pain emotion caused by chronic pain: clinically, most patients are depressed because of neuropathic pain, and after the pain factors are removed or treated, Although pain symptoms disappear temporarily, emotional abnormalities such as depression still exist for a long time, which can in turn cause patients to re-emerge symptoms such as physical pain in certain periods

In the lumbar fifth spinal nerve ligation model alone, due to the long-term existence of the ligation thread, the animal pain and depression caused by nerve damage exist at the same time. The two interact and promote each other and cannot be separated. Therefore, it is difficult to simulate the clinical pain of patients after treatment. The phenomenon of abnormal mood disappears but still exists, so it is impossible to truly understand the mechanism and target of antidepressants on pain from the root cause

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