Pharmaceutical composition for treating diabetes

A composition, technology of diabetes, applied in the field of medicine, can solve problems such as affecting the function

Active Publication Date: 2013-12-04
四川维奥制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese Patent Application No. 200910127364.5 discloses miglitol microcapsule tablets. Although the hygroscopicity of the preparation is avoided, the miglitol preparation is taken with food at the same time, and the dissolution rate should reach more than 80% in 10 minutes to fully exert its medicinal properties. However, the microcapsule preparation is less than 40% in 5 minutes, and the dissolution rate is less than 60% in 10 minutes, which will obviously affect its effect in the small intestine

Method used

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  • Pharmaceutical composition for treating diabetes
  • Pharmaceutical composition for treating diabetes
  • Pharmaceutical composition for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] A pharmaceutical composition for treating diabetes, comprising 50 g of miglitol, 25 g of microcrystalline cellulose, 30 g of pregelatinized starch, 12 g of starch, and 1.5 g of lubricant talcum powder.

[0087] The above-mentioned pharmaceutical composition is prepared into tablets as raw materials.

Embodiment 2

[0089] A pharmaceutical composition for treating diabetes, comprising 50 g of miglitol, 25 g of microcrystalline cellulose, 30 g of pregelatinized starch, and 12 g of starch.

[0090] The above pharmaceutical composition is prepared into capsules as raw materials.

Embodiment 3

[0092] A pharmaceutical composition for treating diabetes, comprising 50 g of miglitol, 30 g of microcrystalline cellulose, 25 g of pregelatinized starch, 14 g of starch, and 1.5 g of lubricant micropowder silica gel.

[0093] The above-mentioned pharmaceutical composition is prepared into tablets as raw materials.

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PUM

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Abstract

The invention belongs to the technical field of medicines and discloses a pharmaceutical composition for treating diabetes. The pharmaceutical composition consists of miglitol, microcrystalline cellulose, pre-gelatinized starch, starch and a lubricant, or the pharmaceutical composition consists of migltol, microcrystalline cellulose, calcium hydrophosphate, starch and the lubricant. The pharmaceutical composition disclosed by the invention is determined through tests of hygroscopicity, dissolution rate, stability and the like, and a pharmaceutical preparation prepared from the pharmaceutical composition has the characteristic of higher quality.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing miglitol as an active ingredient. Background technique [0002] Diabetes (diabetes) is a sugar, protein, A series of metabolic disorder syndromes such as fat, water and electrolytes are clinically characterized by hyperglycemia. In typical cases, polyuria, polydipsia, polyphagia, weight loss and other manifestations may appear, namely "three excesses and one deficiency" symptoms. Diabetes ( Once the blood sugar is not well controlled, it will lead to diabetic complications, leading to failure and lesions of the kidneys, eyes, feet and other parts, which cannot be cured. [0003] Miglitol is a derivative of deoxynojirimycin, which is an oral α-glucosidase inhibitor. The mechanism of its hypoglycemic effect is to reversibly inhibit α-glucosidase in the small intestine, reducing the breakdown of carbohydrates into Glucose, and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/445A61P3/10
Inventor 曹捷高帆周战尚磊
Owner 四川维奥制药有限公司
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