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Application of Chinese medicinal composition to preparation of medicines for preventing and improving particulate matter (PM) 2.5 deposits in lung

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of prevention and improvement of PM2.5 that have not yet appeared, and achieve the effect of improving lung function decline, definite curative effect, and less toxic and side effects

Inactive Publication Date: 2012-08-01
广州白云山潘高寿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no drugs to prevent and improve PM2.5-induced lung deposition

Method used

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  • Application of Chinese medicinal composition to preparation of medicines for preventing and improving particulate matter (PM) 2.5 deposits in lung
  • Application of Chinese medicinal composition to preparation of medicines for preventing and improving particulate matter (PM) 2.5 deposits in lung
  • Application of Chinese medicinal composition to preparation of medicines for preventing and improving particulate matter (PM) 2.5 deposits in lung

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Improving the decline in lung function caused by PM2.5 deposition in the lungs

[0019] In the Guangzhou industrial area and traffic arteries, PM2.5 was sampled with a polytetrafluoroethylene filter membrane of a large flow sampler for 2 consecutive weeks, and the filter membrane loaded with particulate matter was immersed in deionized distilled water, and ultrasonically oscillated 3 times, each time for 40 minutes. Elute particulate matter. The oscillating solution was filtered through gauze, the filtrate was centrifuged at 4°C and 12,000 r / min for 30 minutes, the lower layer suspension was collected, lyophilized and vacuum-dried, and stored in a low-temperature refrigerator for later use. Make up the required concentration with normal saline, mix by ultrasonic oscillation for 15 minutes, store at 4°C, and oscillate before use to fully mix the particles.

[0020] Select SPF level healthy Wistar male rats for use, 60, body weight 220-250g, be divided into 5 ...

Embodiment 2

[0029] Example 2: Improving the respiratory system immune damage caused by PM2.5 deposition in the lungs

[0030]In the Guangzhou industrial area and traffic arteries, PM2.5 was sampled with a polytetrafluoroethylene filter membrane of a large flow sampler for 2 consecutive weeks, and the filter membrane loaded with particulate matter was immersed in deionized distilled water, and ultrasonically oscillated 3 times, each time for 40 minutes. Elute particulate matter. The oscillating solution was filtered through gauze, the filtrate was centrifuged at 4°C and 12,000 r / min for 30 minutes, the lower layer suspension was collected, lyophilized and vacuum-dried, and stored in a low-temperature refrigerator for later use. Make up the required concentration with normal saline, mix by ultrasonic oscillation for 15 minutes, store at 4°C, and oscillate before use to fully mix the particles.

[0031] Select SPF level healthy Wistar male rats for use, 60, body weight 220-250g, be divided ...

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Abstract

The invention relates to application of a Chinese medicinal composition to the preparation of medicines for preventing and improving particulate matter (PM) 2.5 deposits in lung. The Chinese medicinal composition is prepared from the following raw materials in part by weight: 0.5 to 2 parts of animal gall, 6 to 9 parts of ussuriensis fritillary bulb, 2 to 4 parts of almond water and 0.1 to 0.5 part of menthol. The Chinese medicinal composition can improve lung function deterioration and the immunologic injury of a respiratory system which are caused by PM 2.5 deposits in lung obviously, and is a medium-dose Chinese patent medicine which is definite in curative effect and small in toxic and side effect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and improving the deposition of PM2.5 in lungs. Background technique [0002] PM2.5 (particular matter 2.5) refers to fine particulate matter with aerodynamics ≤ 2.5 μm, which accounts for a considerable proportion of atmospheric particulate matter, about 70%. Premier Wen Jiabao of the State Council chaired an executive meeting of the State Council on February 29, 2012, and agreed to release the newly revised "Ambient Air Quality Standards". The scope of mandatory monitoring in various provinces and cities. [0003] Many medical experts have found clinically that the haze weather caused by fine particles is extremely harmful to human health. When the particle size is ≥10 μm, it will be blocked outside the human nose; when the particle size is 2.5 μm-10 μm, ...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P11/00A61K35/413A61K31/045
Inventor 魏大华卢其福黄喜梅刘薇随晶晶周立
Owner 广州白云山潘高寿药业股份有限公司
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