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Simultaneous solid phase extraction and detection method of a plurality of allergic aroma agents in toys

An allergy and fragrance technology, applied in the field of toy safety and analytical chemistry, it can solve the problems of no system and no allergy fragrance, achieve good stability and reproducibility, save analysis time, and remove impurities. simple steps

Active Publication Date: 2013-06-26
SHANGHAI ANPEL SCI INSTR +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fragrance substances detected in these matrices are only individual individuals and do not form a system, nor do they cover the allergic fragrances defined by the new EU Toy Directive
At the same time, there is currently no detection method for allergenic fragrances in toys at home and abroad.

Method used

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  • Simultaneous solid phase extraction and detection method of a plurality of allergic aroma agents in toys
  • Simultaneous solid phase extraction and detection method of a plurality of allergic aroma agents in toys
  • Simultaneous solid phase extraction and detection method of a plurality of allergic aroma agents in toys

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Pretreatment and determination methods of 45 allergic fragrances in wooden toys:

[0029] (1) Extraction:

[0030] Cut the components to be tested into small pieces, accurately weigh 1.0235g of the sample in a grinding bottle, accurate to 0.1mg, add 10mL of tetrahydrofuran, and ensure that all the samples are immersed in the solvent. sample volume or increase the extraction solvent. Seal the mouth of the bottle with a ground plug, conduct ultrasonic extraction at room temperature in an ultrasonic cleaner for 30 min, and centrifuge the extract.

[0031] (2) Remove impurities

[0032] Activate the neutral alumina column (1g / 3mL) with 3-5mL tetrahydrofuran, and be careful not to let the tetrahydrofuran run dry. Load the extract obtained by ultrasound, wash the sample container with 1-2mL tetrahydrofuran, rinse the small column, and dry it in a low vacuum. After filtering membrane to be tested.

[0033] (3) Determination: gas chromatography-mass spectrometry conditions...

Embodiment 2

[0043] Pretreatment and determination methods of 45 allergic fragrances in plush toys:

[0044] (1) Extraction:

[0045] Accurately weigh 1.0764g (accurate to 0.1mg) of red plush, add 10mL of tetrahydrofuran, and ensure that all samples are submerged in the solvent, if not, it is necessary to reduce the weighing amount or increase the extraction solvent. Seal the mouth of the bottle with a ground plug, conduct ultrasonic extraction at room temperature in an ultrasonic cleaner for 30 min, and centrifuge the extract.

[0046] (2) Remove impurities

[0047] Activate the neutral alumina column (1g / 3mL) with 3-5mL tetrahydrofuran, and be careful not to let the tetrahydrofuran run dry. Load the extract obtained by ultrasound, wash the sample container with 1-2mL tetrahydrofuran, rinse the small column, and dry it in a low vacuum. After filtering membrane to be tested.

[0048] (3) Determination: gas chromatography-mass spectrometry conditions are shown in Table 3

[0049] Table...

Embodiment 3

[0055] Pretreatment and determination methods of 45 allergic fragrances in plastic toys:

[0056] (1) Extraction:

[0057] Accurately weigh 1.0753g (accurate to 0.1mg) of purple plastic and add 10mL of tetrahydrofuran to ensure that all samples are submerged in the solvent. If it is not satisfied, it is necessary to reduce the weighing amount or increase the extraction solvent. Seal the mouth of the bottle with a ground plug, conduct ultrasonic extraction at room temperature in an ultrasonic cleaner for 30 min, and centrifuge the extract.

[0058] (2) Remove impurities

[0059] Activate the neutral alumina column (1g / 3mL) with 3-5mL tetrahydrofuran, and be careful not to let the tetrahydrofuran run dry. Load the extract obtained by ultrasound, wash the sample container with 1-2mL tetrahydrofuran, rinse the small column, and dry it in a low vacuum. After filtering membrane to be tested.

[0060] (3) Determination: gas chromatography-mass spectrometry conditions are shown in...

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Abstract

The invention relates to a simultaneous solid phase extraction and detection method of a plurality of allergic aroma agents in toys and aims to establish a detection method of a plurality of allergic aroma agents in toys so as to conveniently, rapidly, accurately and efficiently detect the content of a plurality of allergic aroma agents in toys at the same time. The purpose of the invention is realized as follows: extracting the content of a plurality of allergic aroma agents in toys by the use of a tetrahydrofuran solvent, purifying through a neutral alumina columella, and determining by gaschromatography-mass spectrometry.

Description

technical field [0001] The invention relates to the fields of analytical chemistry and toy safety, in particular to a method for simultaneous detection of various allergic fragrances in toys by solid-phase extraction. Background technique [0002] The quality and safety of toys is directly related to children's physical and mental health. Therefore, as people pay more attention to children's products, toy safety has become a hot topic. In recent years, the quality safety and potential safety hazards of children's toys have attracted more and more attention from all over the world. Many foreign countries, especially more developed countries, have strict management on the quality and safety of children's toys, and the safety requirements for toys are becoming more and more serious. Strict, and the content is also diversified. The banned and restricted substances of allergic fragrances proposed by the European Union is the best example. Allergic fragrances are irritating to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 卫碧文杨荣静于文佳林莉夏敏勇强维
Owner SHANGHAI ANPEL SCI INSTR
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