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Medicament for preventing and treating atherosclerosis and preparation method of granular formulation

A technology for atherosclerosis and drugs, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, can solve problems such as high prices of statins, limitations of long-term clinical application, and economic burden on patients, and achieve protection Endothelial cell function, restore balance, reduce TC effect

Inactive Publication Date: 2013-10-30
FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of statins can produce significant adverse reactions, especially liver damage, which limits the long-term clinical application of these drugs to a certain extent
Secondly, some statins are expensive, and long-term use brings serious economic burden to patients

Method used

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  • Medicament for preventing and treating atherosclerosis and preparation method of granular formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Distill 15g of Ligusticum chuanxiong and 25g of angelica with 14 times the amount of water in Astragalus, Hawthorn, Polygonum multiflorum, Cassia officinalis, Alisma, seaweed, Chuanxiong, and Angelica. Polygonum multiflorum 15g, Cassia 25g use 10 times the amount of 60% ethanol, heat and reflux twice, filter, and the filtrate is decompressed to recover ethanol, and the alcohol extract of the drug is obtained for use; Double the amount of water, decoct with astragalus, Polygonum multiflorum, and Cassia officinalis for 2 hours, add 6 times the amount of water to decoct for 30 minutes, combine the decoction, add the cooking liquid of Angelica chuanxiong and the alcohol extract of Astragalus, Polygonum multiflorum, and Cassia officinalis , mix evenly, use a plate and frame filter press for coarse filtration and fine filtration, and use a three-effect energy-saving concentrator to concentrate the fine filtration to a relative density of 1.15 and a temperature of 60°C; the con...

Embodiment 2

[0022] Distill 20g of Ligusticum chuanxiong and 25g of angelica with 14 times the amount of water in Astragalus, Hawthorn, Polygonum multiflorum, Cassia officinalis, Alisma, seaweed, Chuanxiong and Angelica. Polygonum multiflorum 20g, Cassia 25g use 10 times the amount of 60% ethanol, heat and reflux twice, filter, the filtrate decompresses to recover ethanol, obtain the alcohol extract of the drug, and set aside; use 25g hawthorn, 15g Alisma, and 30g seaweed Double the amount of water, decoct with astragalus, Polygonum multiflorum, and Cassia officinalis for 2 hours, add 6 times the amount of water to decoct for 30 minutes, combine the decoction, add the cooking liquid of Angelica chuanxiong and the alcohol extract of Astragalus, Polygonum multiflorum, and Cassia officinalis , mix evenly, use a plate and frame filter press for coarse filtration and fine filtration, and use a three-effect energy-saving concentrator to concentrate the fine filtration to a relative density of 1.1...

Embodiment 3

[0031] Distill 20g of Ligusticum chuanxiong and 15g of angelica with 14 times the amount of water in Astragalus, Hawthorn, Polygonum multiflorum, Cassia officinalis, Alisma, seaweed, Chuanxiong, and Angelica. Polygonum multiflorum 15g, Cassia 20g use 10 times the amount of 60% ethanol, heat and reflux twice, filter, the filtrate is decompressed to recover ethanol, and obtain the alcohol extract of the drug, and set aside; Hawthorn 20g, Alisma 15g, and seaweed Double the amount of water, decoct with astragalus, Polygonum multiflorum, and Cassia officinalis for 2 hours, add 6 times the amount of water to decoct for 30 minutes, combine the decoction, add the cooking liquid of Angelica chuanxiong and the alcohol extract of Astragalus, Polygonum multiflorum, and Cassia officinalis , mix evenly, use a plate and frame filter press for coarse filtration and fine filtration, and use a three-effect energy-saving concentrator to concentrate the fine filtration to a relative density of 1.1...

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Abstract

The invention relates to a medicament for preventing and treating atherosclerosis and a preparation method of a granular formulation, which are applied to the technical field of medicine. The medicament comprises the components of astragalus mongholicus, hawthorn, polygonum multiflorum, semen cassia, rhizoma alismatis, seaweed, ligusticum wallichii and angelica. The preparation method of the granular formulation comprises the following steps of: adding water to distill ligusticum wallichii and angelica; keeping distillate and decoction; heating and refluxing astragalus mongholicus, polygonum multiflorum and semen cassia twice by using ethanol; filtering; decompressing a filtrate; and recycling ethanol to obtain an ethanol extract of the medicament; adding water to decoct hawthorn, rhizoma alismatis, seaweed, astragalus mongholicus, polygonum multiflorum and semen cassia together; finely filtering; concentrating by using a triple-effect energy-saving concentrator to a relative density; drying a concentrated solution by using a spray drying method to prepare extractum powder; granulating; checking; and sub-packaging in an aluminum plastic film bag to obtain a finished product. The medicament provided by the invention has the advantages of simplicity in components, clear compatibility, less medicament taste, low price, and remarkable curative effect; and animal experiments show that the medicament has the effects of regulating blood lipid, protecting vascular endothelial cells, inhibiting expression of inflammatory factors and remarkably preventing and treating atherosclerosis.

Description

technical field [0001] The invention relates to a Chinese herbal medicine in the technical field of medicine, in particular to a medicine for preventing and treating atherosclerosis and a preparation method of a granule preparation. Background technique [0002] Atherosclerosis (AS) is a complex multifactorial disease, and endothelial cell injury and inflammatory mechanisms play an extremely important role in the occurrence and development of atherosclerosis. Currently, AS is believed to include multiple pathological processes, including damage to the vessel wall, impaired endothelial cell function, local dysfunction, exposure of the subendothelial matrix and collagen, adhesion and aggregation of platelets, production of monocyte chemokines and adhesion molecules, Coagulation and anticoagulant system imbalance, thrombosis and inflammatory response, vascular smooth muscle cell (vascular smooth muscle cell, VSMC) activation, migration, proliferation and extracellular matrix (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K9/16A61P9/10
Inventor 张艳
Owner FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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