Use of polyphenols from pomegranate flowers in preparation of medicaments for treating non-alcoholic fatty liver

Abstract

The invention relates to a user of polyphenols from pomegranate flowers in the preparation of medicaments for treating non-alcoholic fatty liver. A large number of experiments prove that the polyphenols from the pomegranate flowers can obviously reduce rat serum Flns (fluorescence line-narrowing spectroscopy) and IRI (insulin resistance index), delay the first hit in two-hit theory, play a role in preventing further denaturation, putrescence and fibrosis of liver, significantly increase the expression of PON1 (paraoxonase 1) in rat liver tissues, increase the content of HDL (high density lipoprotein) and improve the oxidative stress state in rat bodies.

Description

technical field [0001] The invention relates to the use of pomegranate flower polyphenols in the preparation of medicines for treating non-alcoholic fatty liver. Background technique [0002] With the improvement of living standards, changes in lifestyle and changes in diet structure, the incidence of metabolic diseases is increasing year by year. Among them, diabetes and non-alcoholic fatty liver disease are more common. At present, non-alcoholic fatty liver disease (NAFLD) has been paid more and more attention, but its pathogenesis is still unclear. The "second hit" theory proposed by Day in 1998 believes that various inducements cause insulin resistance (IR), that is, the first hit. Insulin resistance can promote increased peripheral lipolysis, hyperinsulinemia, and increased hepatic fat accumulation. At the same time, it increases the sensitivity of liver cells to damaging factors. The second blow is that factors such as oxidative stress and lipid peroxidation furthe...

AI Technical Summary

Problems solved by technology

[0006] Patients with non-alcoholic fatty liver often have liver dysfunction, and most of the commonly used drugs in clinical treatment are metabolized in the liver, so long-term use may aggravate fat accumulation and liver function damage

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