Paracetamol dry suspension for treating common cold in children

A technology of paracetamol and dry suspension, applied in the directions of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problems of unsatisfactory taste masking effect and the like

Active Publication Date: 2012-09-12
青岛国海生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the children’s cold medicines currently on the market use the method of adding flavoring agents, and the taste-masking effect of acetaminophen, which has a strong bitter taste, is often not ideal.

Method used

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  • Paracetamol dry suspension for treating common cold in children
  • Paracetamol dry suspension for treating common cold in children
  • Paracetamol dry suspension for treating common cold in children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation of acetaminophen dry suspension

[0018] Prescription 1:

[0019]

[0020] Preparation method: pulverize the acetaminophen with a micronizer, wherein about 90% of the particle size is less than 100 μm. Then add diluent, disintegrant, suspending agent, sweetener, bitterness blocker, milk flavor enhancer and mix evenly, then stir and mix with 10% binder aqueous solution to make soft material, use 18-24 mesh Sieve and granulate, and then put it into a drying oven to dry at 60°C or use a fluidized drying bed (inlet air temperature is 120°C to 140°C).

Embodiment 2

[0021] Embodiment 2: Preparation of acetaminophen dry suspension

[0022] Prescription 2:

[0023]

[0024]

[0025] Preparation method: with embodiment 1.

Embodiment 3

[0026] Embodiment 3: Preparation of acetaminophen dry suspension

[0027] Prescription 3:

[0028]

[0029] Preparation method: with embodiment 1.

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Abstract

The invention discloses a paracetamol dry suspension for treating common cold in children. The paracetamol dry suspension comprises paracetamol, a diluting agent, a disintegrating agent, a suspending agent, a sweeting agent, a bitterness retarder, a milk flavor enhancer and an adhesive in a weight ratio of (25-35):(50-70):(3-5):(1-2):(1-2):(1-2):1:(1-2). The paracetamol dry suspension has the advantages of pure milk flavor, no discomfort smell, uniformity in suspension, high absorption, quick response and extreme suitability for being taken by child patients (2-12 ages).

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a dry acetaminophen suspension with milk flavor for treating colds in children. Background technique [0002] Acetaminophen is the most commonly used non-steroidal anti-inflammatory antipyretic analgesic drug for fever caused by the common cold or influenza, and is also used to relieve mild to moderate pain such as headache, joint pain, migraine, toothache , Muscle pain, neuralgia, dysmenorrhea. Not only that, acetaminophen is the most effective and safe antipyretic for children recommended by the World Health Organization, and it has a good effect on fever caused by common cold or influenza in children. [0003] However, due to the bitter taste of acetaminophen, children cannot accept it, so taste-masking measures must be used. Masking the bitterness of drugs can significantly improve the quality of treatment for patients, especially children. At present, the taste-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/167A61P29/00
Inventor 孙雪燕朱燕玲
Owner 青岛国海生物制药有限公司
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