Multilayer pharmaceutical composition that can be dispersed in water and which contains a combination of antimalarial agents

A composition and hydrate technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, anti-infective drugs, etc., can solve the problem of sensitivity reduction

Inactive Publication Date: 2012-09-19
SANOFI SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Resistance of the parasites to these compounds has not been observed to da...

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  • Multilayer pharmaceutical composition that can be dispersed in water and which contains a combination of antimalarial agents
  • Multilayer pharmaceutical composition that can be dispersed in water and which contains a combination of antimalarial agents
  • Multilayer pharmaceutical composition that can be dispersed in water and which contains a combination of antimalarial agents

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Experimental program
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Embodiment approach

[0084] According to another embodiment of the present invention, the pharmaceutical composition comprises:

[0085] - Internal phase compounds for the ferrocene layer:

[0086] ○ 5% to 30% ferroquine,

[0087] ○ 0.2% to 1.0% disintegrant,

[0088] ○ 10% to 40% thinner,

[0089] - Optionally, an external phase compound for the ferrocene layer:

[0090] ○ 0.1% to 1% lubricant,

[0091] ○ 0 to 4.0% sweeteners,

[0092] - internal phase compound for artemisinin or its derivative layer:

[0093] ○ 5% to 20% artemisinin or its derivatives,

[0094] ○ 0 to 10% thinner,

[0095] ○ 8% to 16% codiluent,

[0096] ○ 0.5% to 2% binder,

[0097] ○ 0 to 2% disintegrant,

[0098] - Optionally, an external phase compound for the layer of artemisinin or its derivatives:

[0099] ○ 0 to 1% lubricant,

[0100] ○ 0 to 0.3% flow agent,

[0101] - Compounds for neutral barriers:

[0102] ○ 10% to 30% thinner,

[0103] ○ 0 to 10% co-diluent,

[0104] ○ 0 to 0.5% lubricant,

[0105] ○...

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Abstract

The present invention relates to a multilayer pharmaceutical composition that can be dispersed in water, containing one antimalarial agent in combination with at least one other antimalarial agent. The present invention also relates to a method for producing such a pharmaceutical composition.

Description

technical field [0001] The present invention relates to water-dispersible multilayer pharmaceutical compositions comprising an antimalarial drug in combination with at least one other antimalarial drug. The present invention also includes methods of preparing said pharmaceutical compositions. Background technique [0002] Malaria causes 400 to 900 million cases of fever and 1 to 3 million deaths a year, or one death every 30 seconds. The vast majority of victims were children under 5 and pregnant women. [0003] Despite efforts to reduce the transmission and improve treatment of malaria, little progress has been made since the 1990s. It is estimated that if the incidence of malaria remains at its current level, the mortality rate will double within the next two decades. [0004] The marked increase observed for malaria in recent years is due to several factors, including: [0005] - vectors, Anopheles mosquitoes, which are resistant to conventional and cheap insecticides...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/00A61K31/00
CPCA61K9/2095A61K31/357A61K9/209A61K31/4706A61K9/0095A61P33/00A61P33/06A61P43/00A61K2300/00A61K9/20A61K47/38A61K47/30
Inventor J.钱-索F.埃尔巴兹
Owner SANOFI SA
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