Multilayer pharmaceutical composition that can be dispersed in water and which contains a combination of antimalarial agents
A composition and hydrate technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, anti-infective drugs, etc., can solve the problem of sensitivity reduction
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[0084] According to another embodiment of the present invention, the pharmaceutical composition comprises:
[0085] - Internal phase compounds for the ferrocene layer:
[0086] ○ 5% to 30% ferroquine,
[0087] ○ 0.2% to 1.0% disintegrant,
[0088] ○ 10% to 40% thinner,
[0089] - Optionally, an external phase compound for the ferrocene layer:
[0090] ○ 0.1% to 1% lubricant,
[0091] ○ 0 to 4.0% sweeteners,
[0092] - internal phase compound for artemisinin or its derivative layer:
[0093] ○ 5% to 20% artemisinin or its derivatives,
[0094] ○ 0 to 10% thinner,
[0095] ○ 8% to 16% codiluent,
[0096] ○ 0.5% to 2% binder,
[0097] ○ 0 to 2% disintegrant,
[0098] - Optionally, an external phase compound for the layer of artemisinin or its derivatives:
[0099] ○ 0 to 1% lubricant,
[0100] ○ 0 to 0.3% flow agent,
[0101] - Compounds for neutral barriers:
[0102] ○ 10% to 30% thinner,
[0103] ○ 0 to 10% co-diluent,
[0104] ○ 0 to 0.5% lubricant,
[0105] ○...
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