Vagina pH buffer antibacterial gel and preparation method thereof

A gel and vaginal technology, applied in antibacterial drugs, diseases, aerosol delivery, etc., can solve the problems of drug resistance, serious side effects, etc., achieve strong pH buffering ability, maintain natural moisture, and improve self-purification effect Effect

Inactive Publication Date: 2012-09-26
天津枫盛阳医疗器械技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, polycarbophil gel is used clinically by Hainan Huanglong. For fungal drug treatment, repeated drug treatment will inevitably bring about drug resistance and relatively large side effects

Method used

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  • Vagina pH buffer antibacterial gel and preparation method thereof
  • Vagina pH buffer antibacterial gel and preparation method thereof
  • Vagina pH buffer antibacterial gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]

[0031]

[0032] The above percentages are percentages by weight.

[0033] Weigh polycarbophil and carbomer according to the ratio, add it to the glycerin weighed according to the ratio, stir and disperse until it becomes a paste to obtain a glycerin paste; weigh carboxymethyl chitosan according to the ratio, add it to deionized water, add disodium ethylenediaminetetraacetate, stir to dissolve each component until clear, and obtain carboxymethyl chitosan solution; add carboxymethyl chitosan solution to glycerin paste, stir well, and use triethanolamine solution Adjust the pH to 3.8-4.4 to obtain the gel of polycarbophil and carboxymethyl chitosan; stop stirring, discharge; fill; and obtain the pH buffer antibacterial gel of the present invention after aseptic treatment.

Embodiment 2

[0035]

[0036] Weigh polycarbophil and carbomer according to the ratio, add it to the glycerin weighed according to the ratio, stir and disperse until it becomes a paste to obtain a glycerin paste; weigh carboxymethyl chitosan according to the ratio, add it to deionized water, add EDTA-2na, stir to dissolve each component until clear, and obtain carboxymethyl chitosan solution; add carboxymethyl chitosan solution to glycerin paste, stir evenly, and adjust its pH to 3.8 with triethanolamine solution -4.4, to obtain the gel of polycarbophil and carboxymethyl chitosan; stop stirring, discharge; fill; obtain the pH buffer antibacterial gel of the present invention after aseptic treatment.

Embodiment 3

[0038]

[0039]

[0040] The above percentages are percentages by weight.

[0041] Weigh polycarbophil and carbomer according to the ratio, add it to the glycerin weighed according to the ratio, stir and disperse to a paste to obtain a glycerin paste; weigh chitosan according to the ratio, add it to deionized water, add EDTA-2na , stirring to dissolve each component until clarified to obtain a chitosan solution; add the chitosan solution to the glycerin paste, stir evenly, and adjust its pH to 3.8-4.4 with a triethanolamine solution to obtain polycarbophil and Chitosan gel; stop stirring, discharging; filling; obtain vaginal pH buffer antibacterial gel of the present invention after aseptic treatment. Anti-bacteria (inhibition) rate detection

[0042] According to GB15979-2002, the three embodiments of the present invention are subjected to antibacterial (inhibition) tests. The results of the three tests are shown in Table 2-4. minutes, 20 minutes and Staphylococcus au...

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PUM

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Abstract

The invention provides vagina pH buffer antibacterial gel, a preparation method thereof, and a using method thereof. The gel mainly comprises the components of polycarbophil, carbomer, ethylenediamine tetraacetic acid disodium, chitosan, glycerol, triethanolamine, methyl parahydroxybenzoats and deionized water. By using the weak acidity of polycarbophil and the antibacterial performance of chitosan, the gel can eliminate the source of recurrence of vagina inflammatory diseases and recovers the self-cleaning ability of the vagina. The gel is free from antigen performance, allergy and irritation, and convenient to use, and tissue reaction is avoided.

Description

technical field [0001] The invention relates to a vaginal pH buffer antibacterial gel and a preparation method thereof. Background technique [0002] All vaginitis is caused by certain pathogens, such as Trichomonas vaginalis, Candida albicans, Streptococcus and other infections. But under normal circumstances, the pH value of the vagina is 3.8-4.4, which can inhibit the reproduction and growth of these pathogens, that is, it has the function of self-purification, so even if it is infected with the above-mentioned pathogens, it will not cause inflammation. However, once the vaginal environment is destroyed and the PH value is out of balance, these pathogenic bodies will multiply and cause inflammation. Therefore, to treat vaginitis, we must balance the internal environment, restore the pH value of the vagina, and fundamentally eliminate the living environment of pathogenic bodies. However, most of the current treatments rely solely on drug therapy, whether it is oral antib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/78A61P15/02A61P31/04
Inventor 王洪明洪敏
Owner 天津枫盛阳医疗器械技术股份有限公司
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