Preparation method of ephedrine hydrochloride injection for improving rat blood rheological obstacle

A blood rheology and ephedrine technology, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of undiscovered pharmaceutical compositions and the like

Inactive Publication Date: 2013-10-16
TSINGHUA UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the literature retrieved so far, it is not found that there is a combination of ephedrine, gastrodin and sedanolactone in the pharmaceutical composition.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of ephedrine hydrochloride injection for improving rat blood rheological obstacle
  • Preparation method of ephedrine hydrochloride injection for improving rat blood rheological obstacle
  • Preparation method of ephedrine hydrochloride injection for improving rat blood rheological obstacle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: take by weighing 0.16g of seldanolactone of 98% purity, gastrodin 0.024g of 98% purity, 0.24g of ephedrine of 98% purity, add the polyoxyethylene sorbitan of 5% by volume percentage Monooleate 85ml, stir evenly, make the concentration of the composition of described cedanolactone, gastrodin and ephedrine in the polyoxyethylene sorbitan monooleate aqueous solution of 5% (volume ratio) 5mg / ml.

Embodiment 2

[0011] Embodiment 2: Take by weighing 0.16g of seldanolactone of 98% purity, 0.01g of gastrodin of 98% purity, 0.24g of ephedrine of 98% purity, add the polyoxyethylene sorbitan of 5% by volume percentage Monooleate 82ml, stir evenly, make the concentration of the composition of described sedanolactone, gastrodin and ephedrine in the polyoxyethylene sorbitan monooleate aqueous solution of 5% (volume ratio) 5mg / ml.

[0012] Said sedanolactone is prepared according to the method described in the invention patent application of application number 200880001478.9, named as a pharmaceutical composition for preventing and treating cerebral ischemic stroke and its preparation method, gastrodin and ephedrine are commercially available product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A preparation method of ephedrine hydrochloride injection for improving rat blood rheological obstacle belongs to the field of preparation of drugs for improving biological blood disorders. The preparation method is characterized in that active ingredients of sedanolideat least 98% in purity, gastrodin at least 98% in purity and ephedrine hydrochloride at least 98% in purity are proportionally mixed in 5% tween-80 aqueous solution to make the ephedrine hydrochloride injection, and a combination of the sedanolide, the gastrodin and the ephedrine hydrochloride is 5 mg / l in concentration in the 5% tween-80 aqueous solution. Compared with clinically common drug nimodipine, the ephedrine hydrochloride injection has evidently improved blood viscosity, maximum deformation index of erythrocytes, maximum aggregation index of the erythrocytes and aggregation rate of platelets.

Description

technical field [0001] The invention discloses a preparation method of an ephedrine-containing injection for improving blood rheological disorders, and belongs to the technical field of manufacturing drugs for preventing and treating cerebral ischemia. Background technique [0002] The application number is 200880001478.9, and the Chinese invention patent titled "a pharmaceutical composition for preventing and treating cerebral ischemic stroke and its preparation method" suggests a pharmaceutical composition for preventing and treating ischemic stroke. It is composed of dansinolactone, artebenolactone and gastrodin. Wherein, gastrodin is a commercially available product with a purity of more than 98%, and the purity of sedanolactone and artebenolactone is more than 98%, and correspondingly proposed that the purity of sedanolactone and the purity of 99.17% are Preparation method of 98.32% artebenolactone. The experimental results show that the combination of the three compo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K9/08A61P9/10A61K31/365A61K31/137
Inventor 韩慧婉季梁李衍达丁明玉
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap